Fasoracetam At A Glance

Fasoracetam is a wonderful treatment for ADHD, anxiety, and depression. It works by improving your glutamate-GABA systems. The effect is a lift in mood and a state of easy-going motivation to do what needs to be done. Many users take fasoracetam to transform their attitude toward a task they have been dreading. Once it takes effect, the dread will lift and be replaced by a calm, can-do attitude that gets you through whatever you need to do. It also mildly improves cognitive abilities including the ability to recall information (memory learning). There seems to be no development of tolerance or dependency. Read on for the nootropic guide on Fasoracetam.

Summary

A member of the racetam family, fasoracetam has tremendous promise as an effective nootropic and non-stimulant ADHD medication. In rat studies, it has prevented amnesia and other memory loss impairments, especially ones linked to cholinergic dysfunction.

A growing fan base reports a number of brain health benefits available to those who use fasoracetam as a nootropic. You can use it to relieve anxiety or lift a depressive state and enter a more easy-going yet motivated state. It has a short half-life of between 1 and 2 hours. However, it is potent at low doses and can be safely taken multiple times a day (as long as the total accumulated dose of Fasoracetam in the day doesn’t exceed 50mg).

It was developed by Nippon Shinyaku, a Japanese pharmaceutical company, in an attempt to create a treatment for vascular dementia. The results were disappointing. In 2013, US NeuroFix bought the rights to fasoracetam and began clinical trials again in 2016, this time to investigate its efficacy against Attention Deficit Hyperactivity Disorder, which immediate strong results.

Fasoracetam is currently unregulated. It has not yet been approved by the Food and Drug Administration. However, trials conducted so far demonstrate a low risk of short-term side effects, overdose, addictive dependency or accumulative tolerance, so there is a good chance it will get through. It has been put up for review and phase II proof of concept trials have already been planned.

Benefits of Fasoracetam

Lifts Mood

The most prominent effect reported by users of fasoracetam is the carefree attitude that it brings out in you. Things you have been dreading previously no longer seem that big of a deal. You feel like you can handle whatever comes at you and tedium becomes bearable. In essence, fasoracetam gives you an easy-going, can-do attitude. The benefits of Fasoracetam are quite outstanding!

Reduces Anxiety and Depression

Fasoracetam provides non-addictive, smooth relief from social anxiety without the “buzz” or the “punch” of other anxiety medication. Its primary mechanism of action (that we currently know of) is on receptors of two mood-influencing neurochemicals – glutamate and GABA. The leading theory is that it balances the glutamate system (which is often over-active in anxious individuals) and upregulates GABA receptors (which has a calming effect without sedation or drowsiness). Animal studies match the anecdotal experience, showing subjects are more capable of handling stressful situations when given fasoracetam without signs of excessive social anxiety such as cowering or freezing up.

Fasoracetam & Depression

Improves Focus & Aspects of Cognition

The kind of focus fasoracetam brings about in people is not like the intense, fierce focus of some other racetams (such as phenylpiracetam). The experience is calmer, yet the improvement in focus is clearly present in the aspects of Cognition. Temptations to avoid doing what you need to do fall away. You become a little less susceptible to distraction. Some reports describe an improvement in fluidity of thought when on fasoracetam. With your mood improved and your focus clear, verbal fluency and lateral thinking become easier. If you are looking to improve cognition, make sure you read all about how Fasoracetam can absorb health benefits to improve cognitive function.

Boosts Memory Learning & Prevents Memory Loss or Impairment

Anecdotal evidence clearly points to fasoracetam’s improvements on recall. Users report a significant improvement in memory learning. Studies on rats also demonstrate that fasoracetam improves memory and prevents memory loss & impairment and even amnesia, especially when memory is affected by a lack of choline. The root of the effectiveness of Fasoracetam on memory is its effect on raising the bioavailability of acetylcholine in the brain (increases Acetylcholine). This crucial neurotransmitter is crucial for a variety of cognitive functions and cognitive abilities, including the fact it improves memory and skill acquisition.

Alleviates Symptoms of ADHD (Attention Deficit Hyperactivity Disorder)

The most promising aspect of fasoracetam as far as the pharmaceutical industry is concerned is its potential for treating ADHD. Its efficacy has been studied and shown great potential. It is being investigated in further clinical trials. Some forms of ADHD involve abnormalities in the expression of the glutamatergic gene network. Attention Deficit Hyperactivity Disorder medication has not changed much in decades and consists mostly of general-acting stimulants which create off-target effects. Fasoracetam might be the first new drug in a long time that has the potential to replace the potentially harmful substances currently being given to hyperactive children across the globe (at least for the significant percentage of hyperactive children who were born with an abnormal glutamatergic system).

How it Works

We don’t yet know the exact mechanism of action fasoracetam utilizes to bring about a state of pleasant calm. However, it seems to have an effect on the systems that regulate glutamate, GABA, and increases acetylcholine.
Glutamate: Restoring Balance

Amongst sufferers of ADHD, you are more likely to find abnormal activity in the metabotropic glutamate receptors (mGluRs) that in the general population. When these receptors don’t work like they should, you’re likely to get a glutamate deficiency. Dysregulated glutamate systems don’t just lead to ADHD (Attention Deficit Hyperactivity Disorder). It is also correlated with depression, schizophrenia, epilepsy, and even Alzheimer’s disease.

We know from animal studies that fasoracetam inhibits forskolin-induced cAMP formation in the brain. It does this by stimulating mGluRs. In humans, we have found similar (though less specific) results. Ultimately, fasoracetam increases the activity of glutamate in the cerebral cortex, that can be linked to Alzheimer’s disease.

Scientists working on this drug also hypothesize that fasoracetam might regulate all the receptors in the glutamate system, bringing it under balance as opposed to increasing or decreasing anyone in particular.

Upregulate GABA

Fasoracetam also increases the activity of GABA receptors in the cerebral cortex. We do not know exactly how it affects those receptors after binding, but we do know that their activity is increased. There are a number of other nootropics that calm you and relieve social anxiety via this method. GABA calms neural activity without sedating it.

Glutamate is a precursor to GABA, so the combination of the increase in glutamate activity and the upregulation of GABA receptors means fasoracetam gives your entire GABA-glutamate system a kick and results in significantly larger levels of GABA in the brain compared to baseline.

Fasoracetam GABA

Acetylcholine: Increasing Bioavailability

Like coluracetam and some other nootropics, fasoracetam affects a metabolic pathway known as “high-affinity choline uptake” or HACU. In this process, choline is drawn into your neurons where it is converted into an essential neurotransmitter – acetylcholine (ACh).

Fasoracetam appears to increase acetylcholine synthesis by upregulating HACU and thus bringing more choline into both the cortex and the hippocampus. It also seems to increase the release of acetylcholine into the cerebral cortex. Acetylcholine is associated with learning, memory, and positive emotion.

Many of the racetam family of nootropics are also “cholinergic”, including piracetam and aniracetam. One of the dangers of this is the potential depletion of choline reserves in the brain, leading to headaches, low mood, or brain fog. If you experience these symptoms while taking a cholinergic nootropic, try these nootropic supplement pills or nootropic capsules with choline on the days that you take the drug to help replenish your stores.

Optimal Fasoracetam Dosage

Fasoracetam is a very potent substance. You probably won’t need much to feel a positive effect.

A good dose-range to keep in mind is 5-50mg daily. For many people, 20mg is the sweet spot. Fasoracetam tablets tend to come in 20mg doses for that reason. Due to the low effective half life (around 1 to 2 hours), some users like to take fasoracetam twice a day just before having to do something they don’t normally enjoy.

Users report that administering fasoracetam sublingually (placing the nootropic powders form under your tongue and allowing it to dissolve and absorb health benefits there) produces an enhanced effect. Many users find this method very distasteful due to the bitterness of the nootropic powders.

During the clinical trials on adolescent ADHD, fasoracetam was taken two times a day in doses between 100 and 400mg. No serious ill effects were observed. In addition to that, no accumulative tolerance was observed, either. The effectiveness of Fasoracetam did not diminish, even at such large doses. Addiction or dependence was also not observed, either in human trials or animal experiments.

It seems that with fasoracetam you are very unlikely to overdose, develop tolerance, or develop dependency. However, more trials and human studies need to be conducted before we can say we fully understand fasoracetam. Individuals vary greatly in response to drugs. Start at a dose of Fasoracetam as low as 5mg, and work up gradually. Stop when you find the ideal dose of Fasoracetam for your particular biology. Refrain from taking more than 50mg in one day or you may experience minor side effects.

Side Effects of Fasoracetam

Fasoracetam is a comparatively safe drug, as far as current data and anecdotal evidence can tell.

Any side effects you might experience are likely to be those caused by a temporary lack of choline bitartrate:

Temporary fatigue
Gastrointestinal discomfort
A headache
Low mood

As we’ve already suggested, supplementing with choline bitartrate should protect you against these side-effects, but this is not guaranteed. We do not know the full mechanism of action of fasoracetam, so if you still experience side-effects even while supplementing with choline bitartrate, just stop taking fasoracetam.

Fasoracetam is metabolised by the kidneys, so if you have any pre-existing kidney condition, consult a medical professional before taking it. Avoid taking it altogether if you are pregnant or breastfeeding.

Stacking Fasoracetam with Phenibut & other Nootropic Stacks

By stacking fasoracetam and Phenibut, you can maximize the mood lifting properties of both. Phenibut is a much stronger anti-anxiolytic nootropic. If you suffer from particularly extreme anxiety or acute anxiety attacks, these might be good nootropic stacks to have at hand.

Some users have even used fasoracetam to help them through Phenibut withdrawal. Phenibut develops a level of dependency if you use it regularly, and we believe that fasoracetam helps reduce the symptoms of withdrawal by restoring normal functioning of GABA receptors.

Noopept Cognitive Enhancers

Noopept is another of the cognitive abilities enhancer nootropics. It is difficult to build a tolerance for, so you could probably take this stack daily without negative consequences. It produces much stronger effects of cognitive enhancement that fasoracetam. A common side effect of Noopept, however, is anxiety and irritability, which fasoracetam can completely elevate. As one Reddit user excitedly reported, and from other user experiences; these two nootropic cognitive enhancers compliment each other perfectly.

Racetam Nootropics

Fasoracetam nootropic stacks will with other nootropics from the racetam family. If you’d like the hardcore focus and energy of phenylpiracetam combined with the background calm and positivity of fasoracetam, for example, you might like to experiment with stacking the two. Try 150mg of phenylpiracetam with 20mg of fasoracetam. Or, if you want enhanced mood improvements without the punch of phenibut, you could try combining fasoracetam with coluracetam.

Whenever combining two or more racetams, consider supplementing with choline to provide your brain with the raw materials it needs for these nootropics to do their job. If you’re looking to improve your brain health, Nootropic stacks are worth investigating.

Fasoracetam Productivity

Where to Buy Fasoracetam

At the time of writing, you cannot buy fasoracetam offline. If you want to go through a highly trusted source for your fasoracetam, buy Fasoracetam through Pure Nootropics, a nootropic store that’s well known and liked by the nootropics community.

Closing Thoughts & Effectiveness of Fasoracetam

Fasoracetam is still an experimental drug, yet early evidence and anecdotal reports suggest it is both very safe and highly effective nootropic in terms of reducing social anxiety, improving mood and focus and even memory, especially in individuals who suffer from an abnormal glutamatergic system.

If you’re looking for a safe way to transform how you experience a particularly dreaded or tedious task at work, or for something to have at hand in case you have an anxiety attack, fasoracetam might be perfect for you.

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Sources:

https://adaa.org/understanding-anxiety/panic-disorder-agoraphobia/symptoms

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