Coluracetam’s History

Coluracetam is a subtle mood-enhancing nootropic which can also enhance working memory and creativity. It works by increasing the brain’s production of acetylcholine, a molecule that acts as a neurotransmitter that affects neuroplasticity, arousal, and reward, as well as alertness and memory.

As a member of the drug family “Racetam”, coluracetam works well in nootropic stacks with a number of other nootropics and substances. Synthesised in 2005 by the Mitsubishi Tanabe Pharma Corporation, coluracetam was a derivative of piracetam and an attempt to create a new treatment for Alzheimer’s disease. It was later in-licensed by BrainCells Inc to investigate its potential for treating depression with very promising results. Read on for the full Coluracetam nootropic guide.

Benefits and Effects

The most profound subjective effects of coluracetam appear to be an increase in mood and, for some people, a visual vividness which makes the world look very “high definition” and colorful. It lacks the energy-boost of other racetams, which makes it work well in combination with stimulants. It’s a good choice if you just want to feel better without feeling “buzzed” or “wired”.

Coluracetam effects

Depression and Anxiety

Coluracetam was found to have significant positive effects on people suffering from major depressive disorder (MDD) and generalized anxiety disorder (GAD). In brief, major depressive disorder is what most people think about when they think “depression”. It’s characterized by an extended low mood and lack of motivation for normal things that persists across various activities. Many people experience MDD for brief periods of time, while others suffer through it constantly. Generalised anxiety disorder is a little different. It is characterized by excessive and uncontrollable apprehension about everyday matters.

BrainCell Inc studied coluracetam’s potential to treat depression by dosing subjects with 80mg daily for three days (which is a higher dose than we would recommend, by the way). 36% of subjects scored better on a depression assessment test after two doses.

Anecdotal reports reflect these results some people feel much happier on Coluracetam, whereas others experience a far more subtle effect. In the studies, the largest effect was found on patients who didn’t respond to standard antidepressant medication.

Like most things in biology, depression is a spectrum. Many of us have felt “depressed” or “anxious” without actually having “depression” or an “anxiety disorder”. You don’t need to have been born with a faulty brain. Normal people can be pushed by life circumstances to certain thresholds or breaking-points.

Coluracetam seems to facilitate feelings of happiness and positivity by increasing the amount of acetylcholine in the brain. Some other racetams affect how acetylcholine is used by the brain, which might explain the energetic boost of those substances. Acetylcholine is used for a number of things, and one of them is a positive emotion. It could be that by increasing the amount of acetylcholine in the brain, your brain now has the raw materials necessary to elevate your mood naturally or with natural nootropics.

Besides MDD and GAD, sufferers of SAD (seasonal affective disorder, or feeling depressed in the winter time) have reported a great effect from coluracetam. It improves your outlook on work and life without giving you a “buzz”.

Memory and Learning

Acetylcholine is known for being involved in memory and learning. Scopolamine (a drug that reduces acetylcholine) impairs your ability to acquire new information. Disrupting your supply of acetylcholine to your hippocampus results in quite devastating forgetfulness.

Coluracetam does not have such a big boost in cognition as some other nootropics, but it does have an effect and for some people, it is quite pronounced. BrainCells Inc conducted a study on rats to test coluracetam’s cognitive effects. The rats were given a mentally-impairing substance, followed by coluracetam and then they were tested with a Morris Water Maze. Coluracetam counteracted the effects of the neurotoxin very effectively, and impaired rats were still able to complete the maze.

We have no studies to turn to yet investigating coluracetam’s effects on human cognition, but self-reports show that some people find it makes them more alert, focused, motivated, and creative, as well as improving working memory and the incorporation of new information. Some users find their mind becomes more fluid and, strangely enough, able to take a step back and look at things from a “big picture” perspective. If you experience the same effect, coluracetam might be a good nootropic to take to enhance strategy sessions, brainstorming, or planning.


The biggest mystery of coluracetam is its effects on our subjective experience of vision. Acetylcholine is not involved much in our visual processes, so another mechanism of action is probably at play. Regardless, a lot of users find this nootropic makes the world look in “ultra-HD”. Things look sharper, brighter and more colorful. There are few productive applications for this effect unless, perhaps, you are an artist or some other profession where aesthetic inspiration is a part of the process.

Some users also experience greater “immersion”. You know what immersion is when you’ve watched a movie and felt completely engrossed so that someone needs to say your name several times to get your attention. This might have a similar root cause as the effect of the world looking brighter and more vivid, although immersion is not specific to visual stimulus. For all these reasons, users also find coluracetam to enhance meditation.

How it Works

The mechanisms of action (as well as structure) appear to be very distinct from other racetam compounds like piracetam or aniracetam. It increases a process called high affinity choline uptake enhancer (or HACU for short). This means more choline enters your cholinergic neurons. Choline is an essential nutrient, related to B vitamins but not quite in the same family. Once inside a neuron, choline converted into acetylcholine (ACh), a molecule that performs many roles in the body, including as a neurotransmitter associated with positive emotion and making new memories.

By supporting high affinity choline uptake enhancer HACU coluracetam causes more choline to move into brain cells, so it’s recommended you supplement with choline when taking coluracetam. It’s not going to cause a strong choline deficiency, but it’s still wise to provide the process with an abundance of raw material.

Coluracetam also seems to raise the activity of AMPA in the brain. AMPA acts as an excitatory neurotransmitter. That doesn’t mean it will make you feel more excited but rather that your cholinergic neurons may fire better.

The effects on eyesight, however, are not well understood. Acetylcholine plays no direct part in vision. The sometimes strong effect of “HD vision” and vividness of color, therefore, is probably achieved through a different process.

It seems that healthier cholinergic neurons are less affected by coluracetam than impaired cholinergic neurons. Rat studies showed that coluracetam can preserve high affinity choline uptake enhancer in rats that were given a neurotoxin that inhibits it. In the unimpaired rats, however, high affinity choline uptake enhancer didn’t increase much. This might be why sufferers of depression have found coluracetam to be particularly powerful if they are resistant to other treatments. Depression can be caused by a huge variety of things. Perhaps some people are depressed because of a natural impairment of high affinity choline uptake enhancer, making coluracetam the only drug out there that can put their brain chemistry back into healthy working order.

Coluracetam review

Coluracetam Dosage

Users of coluracetam report an effective range of 3 to 35 mg daily. Tolerance varies greatly between people, as with any drug, so we advise you to start with a low dose and gradually increase your exposure until you find an effective amount. Tolerance of coluracetam can increase if you use it daily. If you find you need to take increasing amounts to feel an effect, consider a detox. It takes 1 to 2 weeks for your tolerance to this particular drug to return to baseline. There might also be a cross-tolerance effect with other racetams, so plan accordingly if you’re stacking with or separately using nootropics such as piracetam or oxiracetam.

Side Effects

You would be a very rare case to experience side effects from coluracetam. Taken at the coluracetam dosage we recommend produces no side effects in most people. If you ‘are new to nootropics you may develop a headache, and that is true of all nootropics. With coluracetam, you can minimize the chance of a newbie-headache by supplementing with choline (see below). It also appears to be completely non-addictive, lacking any way to act as a “chemical hook”. As with all things that benefit you, you might develop a habit that is then hard to break, but there is nothing in the drug itself that makes it addictive.

Nootropic Stacking

Coluracetam is an excellent addition to many nootropic stacks. It works safely with many other popular nootropics, from Noopept to modafinil to piracetam. Its main effect of boosting mood pairs very well with other nootropics which focus more on energy and cognition.


Combining L-Theanine and Coluracetam can dramatically improve your mood. L-Theanine is a compound found naturally in tea leaves that have a calming effect on users. It’s a safe choice for most nootropic stacks and is sometimes used by people who experience some unpleasant anxiety when taking energy-increasing or focus-boosting nootropics such as modafinil or piracetam. It can often solve the anxiety problem immediately.

In addition to calming you, l-theanine can also increase your capacity to pay attention, to focus, and even to learn. Add to that the positive mood and additional learning benefits that coluracetam can produce, and you may have a very effective stack for getting you through stressful times or to work or study most effectively.


Coluracetam works synergistically with other racetams. For example, oxiracetam is a powerful nootropic that affects a wide array of cognitive enhancing abilities, from improved memory to motivation to attention span and more, and can be used safely with coluracetam. Combining oxiracetam with coluracetam and l-theanine could give you a stack that dramatically improves your processing power while keeping you calm and happy at the same time. You could try stacking with any of the other racetams, such as pramiracetam, aniracetam, or phenylpiracetam.
Choline Supplementation

Like most racetams, coluracetam nootropic stacks well with a choline source, such as Alpha GPC or CDP choline. Since coluracetam works by converting choline to acetylcholine, increasing your choline intake gives it more raw materials to work with and might enhance the effect. The recommended doses for supplemental choline is 300 mg to 600 mg a day if you’re stacking with Alpha GPC and 250 mg daily to 750 mg a day if you’re using CDP choline.

Where to Buy Coluracetam

Coluracetam mgColuracetam Choline Uptake HACU is not easy to find. Nixest makes it simple and secure. Click “ADD TO CART” on this page and you’ll be taken to a partner page where you can buy coluracetam directly from the original manufacturers. This gives you wholesale prices, making it much cheaper for you if you go through Nixest. You also enjoy automatic buyer protection and your purchase can be shipped for free anywhere in the USA, Australia, and the United Kingdom.

Closing Thoughts

We all have days when we feel low, unmotivated, and mentally foggy (brain fog). Coluracetam has profound effects for some people on working memory, mental fluidity and improved memory, and most of all it induces a state of clear-headed positivity. The mood-enhancing effect is relatively rare in the world of nootropics. Most affect cognition and motivation in a mood-neutral way. This, combined with coluracetam’s unique mechanism of action in the brain, means that it makes a particularly great addition to almost any stack, allowing you to keep all the benefits of the stack and add to that a feeling of positivity and optimism. Negative mental states can lead people to make bad decisions, no matter how good their working improved memory or attention span. Plus, it feels good to feel good!

Try coluracetam first as a standalone so you know how it affects your specific biology, and use it to enhance your state and sharpen your mind for activities such as strategy sessions or interpersonal work.

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