Nootropic capsules

Fasoracetam

At a Glance

Fasoracetam is a wonderful treatment for ADHD, anxiety and depression. It works by improving your glutamate-GABA systems. The effect is a lift in mood and a state of easy-going motivation to do what needs to be done. Many users take fasoracetam to transform their attitude toward a task they have been dreading. Once it takes effect, the dread will lift and be replaced by a calm, can-do attitude that gets you through whatever you need to do. It also mildly improves cognitive abilities including the ability to recall information (memory learning). There seems to be no development of tolerance or dependency. Read on for the nootropic guide on Fasoracetam.

Summary

A member of the racetam family, fasoracetam has tremendous promise as an effective nootropic and non-stimulant ADHD medication. In rat studies, it has prevented amnesia and other memory loss impairments, especially ones linked to cholinergic dysfunction.

A growing fan base reports a number of brain health benefits available to those who use fasoracetam as a nootropic. You can use it to relieve anxiety or lift a depressive state and enter a more easy-going yet motivated state. It has a short half-life of between 1 and 2 hours. However, it is potent at low doses and can be safely taken multiple times a day (as long as the total accumulated dose of Fasoracetam in the day doesn't exceed 50mg).

It was developed by Nippon Shinyaku, a Japanese pharmaceutical company, in an attempt to create a treatment for vascular dementia. The results were disappointing. In 2013, US NeuroFix bought the rights to fasoracetam and began clinical trials again in 2016, this time to investigate its efficacy against Attention Deficit Hyperactivity Disorder, which immediate strong results.

Fasoracetam is currently unregulated. It has not yet been approved by the Food and Drug Administration. However, trials conducted so far demonstrate a low risk of short-term side effects, overdose, addictive dependency or accumulative tolerance, so there is a good chance it will get through. It has been put up for review and phase II proof of concept trials have already been planned.

Benefits of Fasoracetam

Lifts Mood

The most prominent effect reported by users of fasoracetam is the carefree attitude that it brings out in you. Things you have been dreading previously no longer seem that big of a deal. You feel like you can handle whatever comes at you and tedium becomes bearable. In essence, fasoracetam gives you an easy-going, can-do attitude. The benefits of Fasoracetam are quite outstanding!

Reduces Anxiety and Depression

Fasoracetam provides non-addictive, smooth relief from social anxiety without the “buzz” or the “punch” of other anxiety medication. Its primary mechanism of action (that we currently know of) is on receptors of two mood-influencing neurochemicals - glutamate and GABA. The leading theory is that it balances the glutamate system (which is often over-active in anxious individuals) and upregulates GABA receptors (which has a calming effect without sedation or drowsiness). Animal studies match the anecdotal experience, showing subjects are more capable of handling stressful situations when given fasoracetam without signs of excessive social anxiety such as cowering or freezing up.

Fasoracetam & Depression

Improves Focus & Aspects of Cognition

The kind of focus fasoracetam brings about in people is not like the intense, fierce focus of some other racetams (such as phenylpiracetam). The experience is calmer, yet the improvement in focus is clearly present in the aspects of Cognition. Temptations to avoid doing what you need to do fall away. You become a little less susceptible to distraction. Some reports describe an improvement in fluidity of thought when on fasoracetam. With your mood improved and your focus clear, verbal fluency and lateral thinking become easier. If you are looking to improve cognition, make sure you read all about how Fasoracetam can absorb health benefits to improve cognitive function.

Boosts Memory Learning & Prevents Memory Loss or Impairment

Anecdotal evidence clearly points to fasoracetam's improvements on recall. Users report a significant improvement in memory learning. Studies on rats also demonstrate that fasoracetam improves memory and prevents memory loss & impairment and even amnesia, especially when memory is affected by a lack of choline. The root of effectiveness of Fasoracetam on memory is its effect on raising the bioavailability of acetylcholine in the brain (increases Acetylcholine). This crucial neurotransmitter is crucial for a variety of cognitive functions and cognitive abilities, including the fact it improves memory and skill acquisition.

Alleviates Symptoms of ADHD (Attention Deficit Hyperactivity Disorder)

The most promising aspect of fasoracetam as far as the pharmaceutical industry is concerned is its potential for treating ADHD. Its efficacy has been studied and shown great potential. It is being investigated in further clinical trials. Some forms of ADHD involve abnormalities in the expression of the glutamatergic gene network. Attention Deficit Hyperactivity Disorder medication has not changed much in decades, and consists mostly of general-acting stimulants which create off-target effects. Fasoracetam might be the first new drug in a long time that has the potential to replace the potentially harmful substances currently being given to hyperactive children across the globe (at least for the significant percentage of hyperactive children who were born with an abnormal glutamatergic system).

How it Works

We don't yet know the exact mechanism of action fasoracetam utilises to bring about a state of pleasant calm. However, it seems to have an effect on the systems that regulate glutamate, GABA, and increases acetylcholine.
Glutamate: Restoring Balance

Amongst sufferers of ADHD, you are more likely to find abnormal activity in the metabotropic glutamate receptors (mGluRs) that in the general population. When these receptors don't work like they should, you're likely to get a glutamate deficiency. Dysregulated glutamate systems don't just lead to ADHD (Attention Deficit Hyperactivity Disorder). It is also correlated with depression, schizophrenia, epilepsy, and even Alzheimer's disease.

We know from animal studies that fasoracetam inhibits forskolin-induced cAMP formation in the brain. It does this by stimulating mGluRs. In humans, we have found similar (though less specific) results. Ultimately, fasoracetam increases the activity of glutamate in the cerebral cortex, that can be linked to Alzheimers disease.

Scientists working on this drug also hypothesise that fasoracetam might regulate all the receptors in the glutamate system, bringing it under balance as opposed to increasing or decreasing any one in particular.

Upregulate GABA

Fasoracetam also increases the activity of GABA receptors in the cerebral cortex. We do not know exactly how it affects those receptors after binding, but we do know that their activity is increased. There are a number of other nootropics that calm you and relieve social anxiety via this method. GABA calms neural activity without sedating it.

Glutamate is a precursor to GABA, so the combination of the increase in glutamate activity and the upregulation of GABA receptors means fasoracetam gives your entire GABA-glutamate system a kick and results in significantly larger levels of GABA in the brain compared to baseline.

Fasoracetam GABA

Acetylcholine: Increasing Bioavailability

Like coluracetam and some other nootropics, fasoracetam affects a metabolic pathway known as “high affinity choline uptake” or HACU. In this process, choline is drawn into your neurons where it is converted into an essential neurotransmitter - acetylcholine (ACh).

Fasoracetam appears to increase acetylcholine synthesis by upregulating HACU and thus bringing more choline into both the cortex and the hippocampus. It also seems to increase the release of acetylcholine into the cerebral cortex. Acetylcholine is associated with learning, memory, and positive emotion.

Many of the racetam family of nootropics are also “cholinergic”, including piracetam and aniracetam. One of the dangers of this is the potential depletion of choline reserves in the brain, leading to headaches, low mood, or brain fog. If you experience these symptoms while taking a cholinergic nootropic, try these nootropic supplement pills or nootropic capsules with choline on the days that you take the drug to help replenish your stores.

Optimal Fasoracetam Dosage

Fasoracetam is a very potent substance. You probably won't need much to feel a positive effect.

A good dose-range to keep in mind is 5-50mg daily. For many people, 20mg is the sweet spot. Fasoracetam tablets tend to come in 20mg doses for that reason. Due to the low effective half life (around 1 to 2 hours), some users like to take fasoracetam twice a day just before having to do something they don't normally enjoy.

Users report that administering fasoracetam sublingually (placing the nootropic powders form under your tongue and allowing it to dissolve and absorb health benefits there) produces an enhanced effect. Many users find this method very distasteful due to the bitterness of the nootropic powders.

During the clinical trials on adolescent ADHD, fasoracetam was taken two times a day in doses between 100 and 400mg. No serous ill effects were observed. In addition to that, no accumulative tolerance was observed, either. The effectiveness of Fasoracetam did not diminish, even at such large doses. Addiction or dependence was also not observed, either in human trials or animal experiments.

It seems that with fasoracetam you are very unlikely to overdose, develop tolerance, or develop dependency. However, more trials and human studies need to be conducted before we can say we fully understand fasoracetam. Individuals vary greatly in response to drugs. Start at a dose of Fasoracetam as low as 5mg, and work up gradually. Stop when you find the ideal dose of Fasoracetam for your particular biology. Refrain from taking more than 50mg in one day or you may experience minor side effects.

Side Effects of Fasoracetam

Fasoracetam is a comparatively safe drug, as far as current data and anecdotal evidence can tell.

Any side effects you might experience are likely to be those caused by a temporary lack of choline bitartrate:

Temporary fatigue
Gastrointestinal discomfort
Headache
Low mood

As we've already suggested, supplementing with choline bitartrate should protect you against these side-effects, but this is not guaranteed. We do not know the full mechanism of action of fasoracetam, so if you still experience side-effects even while supplementing with choline bitartrate, just stop taking fasoracetam.

Fasoracetam is metabolised by the kidneys, so if you have any pre-existing kidney condition, consult a medical professional before taking it. Avoid taking it altogether if you are pregnant or breastfeeding.

Stacking Fasoracetam with Phenibut & other Nootropic Stacks

By stacking fasoracetam and phenibut, you can maximise the mood lifting properties of both. Phenibut is a much stronger anti-anxiolytic nootropic. If you suffer from particularly extreme anxiety or acute anxiety attacks, these might be good nootropic stacks to have at hand.

Some users have even used fasoracetam to help them through phenibut withdrawal. Phenibut develops a level of dependency if you use it regularly, and we believe that fasoracetam helps reduce the symptoms of withdrawal by restoring normal functioning of GABA receptors.

Noopept Cognitive Enhancers

Noopept is another of the cognitive abilities enhancer nootropics. It is difficult to build a tolerance for, so you could probably take this stack daily without negative consequences. It produces much stronger effects of cognitive enhancement that fasoracetam. A common side effect of noopept, however, is anxiety and irritability, which fasoracetam can completely elevate. As one Reddit user excitedly reported, and from other user experiences; these two nootropic cognitive enhancers compliment each other perfectly.

Racetam Nootropics

Fasoracetam nootropic stacks will with other nootropics from the racetam family. If you'd like the hardcore focus and energy of phenylpiracetam combined with the background calm and positivity of fasoracetam, for example, you might like to experiment with stacking the two. Try 150mg of phenylpiracetam with 20mg of fasoracetam. Or, if you want enhanced mood improvements without the punch of phenibut, you could try combining fasoracetam with coluracetam.

Whenever combining two or more racetams, consider supplementing with choline to provide your brain with the raw materials it needs for these nootropics to do their job. If you're looking to improve your brain health, Nootropic stacks are worth investigating.

Fasoracetam Productivity

Where to Buy Fasoracetam

At the time of writing, you cannot buy fasoracetam offline. If you want to go through a highly trusted source for your fasoracetam, buy Fasoracetam through Pure Nootropics, a nootropic store that's well known and liked by the nootropics community.

Closing Thoughts & Effectiveness of Fasoracetam

Fasoracetam is still an experimental drug, yet early evidence and anecdotal reports suggest it is both very safe and highly effective nootropic in terms of reducing social anxiety, improving mood and focus and even memory, especially in individuals who suffer from an abnormal glutamatergic system.

If you're looking for a safe way to transform how you experience a particularly dreaded or tedious task at work, or for something to have at hand in case you have an anxiety attack, fasoracetam might be perfect for you.

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Nootropic Pills

Picamilon

At a Glance

Picamilon is a nutritional supplement so powerful that it acts like a nootropic drug. By combining a nutrient and a neurotransmitter, this nootropic naturally optimises your brain cells. You'll experience a boost in cognitive function and a state of smooth motivation while simultaneously feeling calmer and more relaxed.

Summary

Developed in 1969 by the Russian facility, The All Union Vitamin Research Institute, picamilon was first used as a Russian pharmaceutical from 1986 onwards to treat people with memory and learning problems, loss of brain cells blood circulation, sufferers of brain trauma, and patients with chronic alcoholism.

Over the 1960s and 70s, the Russian scientific community was interested in finding ways to promote mental health through use of the neurotransmitter GABA. The biggest problem with this approach was that GABA could not cross the blood brain barrier with ease. Combining it with niacin vitamin B3 solved this problem while producing additional Picamilons benefits.

Its primary function is to quickly restore alertness in mind and body in those who feel drained by stress. Picamilon is loved by those who need their minds to perform at their best while also struggling with stress and anxiety, from students to executives.

Benefits and Effects

Focused, relaxed, and stress-free. There are many people at work today who would love to feel this way more often. Many students, for example, suffer under highly stressful circumstances while simultaneously being required to use the full capacity of their minds. Managers, team leaders, and executives find themselves under increasing mountains of stress and responsibility, not to mention the family they may be taking care of. Yet every day they have to be sharp and on-the-ball.

Picamilon stimulates neural efficiency while simultaneously producing a calming effect of Picamilon. If that sounds like a paradox, imagine a time when you were so stressed that you didn't know what to do next. Your heart was racing. You were in fight-or-flight mode, and you were primed for action. Somehow, nothing gets done, and if it does, it's rushed and faulty. You end up making bad decisions based on emotionality rather than logic or reason.

The mind works better when it is calm. The literature on anxiety disorder and performance is quite clear. More anxiety, less performance. When your mind is clear and focused, you know what to do next. You sit down in the morning and started crushing your first task. You are relaxed, calm, and yet your brain is also firing on all cylinders, working faster and more efficiently, seeing more connections, coming up with better ideas, and making better decisions.

Anxiety Reduction

GABA-promoting relaxant supplements like picamilon has been proven to relieve subjects of chronic anxiety and stress. It also promotes alpha brain waves, which studies show indicate a mental health and state of heightened creativity. Users report that the anxiolytic effect or the anti-anxiety effect of picamilon is similar to that of L-theanine. It brings you into a calm and focused state.

Picamilon VS Phenibut

Note: If you suffer from severe anxiety, you might consider phenibut instead of picamilon. Phenibut is much stronger than picamilon. This is not such a good thing for the average person, as it can induce a sedative effect of Picamilon. However, if your anxiety is strong enough a slight feeling of sedation might be well worth it. Although picamilon also has a tranquilizing effect, it does not induce any muscle relaxation or drowsiness.

GABA Vs Phenibun

Improve Mood & Motivation

Activating GABA not only inhibits anxiety. It also stimulates the release of endorphins - the same biochemical group that enter your bloodstream after working out or after sex. Picamilon's effect is somewhat more mild, of course, but the same chemicals are there to give you a mild “glow” feeling that can help you overcome self-doubt and inconvenient dips in motivation.

Cognitive Enhancement

Niacin, one of the active components of picamilon, increases cerebral circulation. What that means is the blood vessels surrounding and permutating your grey matter become looser and more efficient. Picamilon is even better at promoting blood flow than prescription drug “vasodilators” (drugs that widen your blood vessels). Efficient blood flow allows your neurons to receive an abundance of raw materials, and waste products are picked up and transported away from the brain quickly. It keeps your mind alert, awake, and efficient.

Improve Working Memory

As this summary of picamilon clinical trials and studies suggests, the supplement enhances learning, short-term memory and long-term memory in rats. It has also been used explicitly to treat sufferers of memory and attention disorders. The reasons for this are unclear, though they likely have something to do with the increase of blood flow to the brain through the brain cells. Thought literally takes energy and resources from your body, and inefficient blood flow can allow hard-working neurons to “clog up” with the “waste-products” of thought. Memory requires firing the same neural pathways repeatedly, so it would stand to reason that clearing those pathways of debris and refuelling them would promote recall.

Lower blood pressure

If you suffer from hypertension (which is often increased by stress and anxiety), picamilon is likely to bring your blood pressure down. The other side of this effect is the danger it represents to anyone suffering from the opposite problem - hypotension or low blood pressure. Hypotension is defined as a blood pressure of less than 90/60, which you can check yourself with an inexpensive home blood pressure kit. If in any doubt do not take picamilon or any other vasodilators and consult your medical practitioner.

Better Sleep

Low GABA receptor levels can result in insomnia and night-time anxiety. There's nothing worse than lying awake at night, an anxious feeling in your chest that seems to be caused by nothing at all, unable to get any sleep as the morning (with all its responsibilities), rushes slowly creeps towards you. By getting more activating GABA into the brain, picamilon supplementation can optimise GABA receptor levels and fix any sleep or health issues that have resulted from the deficiency.

How it Works

Picamilon works via two different metabolic mechanisms of action. One produces the cognitive enhancements, and the other produces the calming effect. The two of them together can allow you to slip into a state of calm, focused productivity.

The two active molecules in picamilon are niacin and GABA.

Niacin vitamin B3 is an essential nutrient that easily passes through the blood-brain barrier. Once inside, it acts as a vasodilator - that is, a substance that dilates blood vessels thus increasing blood flow to the area. The rise in blood flow is what scientists attribute to picamilon's ability to enhance cognitive processes.

GABA is an important neurotransmitter that lowers the “excitatory state” of neurons. This doesn't only mean they fire less often. It also means your neurons fire less sporadically. Part of anxiety is an over-stimulated mind that cannot disentangle itself from all the irrelevancies that life tries to tell us are important. Someone who is chronically anxious (say, in sufferers of PTSD or people who get severe panic attacks or bouts of paranoia), has a brain that is telling them that almost everything around them is a potential threat. It's firing at irrelevant stimuli. By calming down any over-excitement of your neurons, GABA helps you to focus on what's important and ignore distraction.

The combination of these two molecules makes picamilon powerful. The Russian research facility that developed the drug was trying to find a way to help GABA across the blood-brain barrier. Since niacin vitamin B3 passes into the brain so easily, they tried binding it to GABA molecules. The combination worked like a treat, allowing niacin to pull GABA molecule into the brain at a higher than normal rate. From there, the two molecule complex is hydrolysed (broken down) into its two constituent molecules. They can then be metabolised by the brain as we've described above in large quantities, producing the effects of high cognitive performance and memory (through the vasodilation of niacin) and calmness and relaxation (via the anxiolytic effect: relaxation of GABA).

Note that taking GABA and niacin separately in nootropic stacks will not produce the same effect. In picamilon, the GABA and niacin are bound together on a molecular level, to be disentangled only after they cross the blood-brain barrier.

Picamilon Dosage

We have not had many trials on the correct dosing for picamilon. However, from anecdotal evidence and the experience of hundreds of users, the nootropic community has reached a consensus on a wise dosage of picamilon. Dosage ranges from 50 to 400 mg per day.

If you are new to nootropics, start out even lower with a micro-dose of 10 mg per day. Gradually ramp up the dosage. This way you can check at a very safe dose for any signs of allergy or skin rash. You will also be able to identify your ideal tolerance, which may well be lower than 50 mg per day.

Accumulative tolerance will occur if you take picamilon every day. Take regular breaks and keep track of how much you take in order to prevent tolerance-creep.

Overdosing with picamilon is extremely rare, but it should remain a concern. Due to the fact that tolerance to the drug can build up, and that sufferers of chronic anxiety are more likely than the average person to take too much of a medication, remember to never exceed more than 400mg a day. The few cases of picamilon overdose recorded have to do with blood pressure lowering too far and increase in blood sugar levels (which is particularly dangerous for people with diabetes).

Picamilon Side Effects

There have been very few (and very minor) Picamilon side effects ever recorded from picamilon ingestion. It is generally considered to be a safe substance. The largest risk for serious damage is present if you have low blood pressure. If you have hypotension or are prone to it, be sure to consult a medical practitioner before taking picamilon, and tell them the nature of the supplement. They may be able to turn you towards another anxiety medication that is less risky for you.

More typical negative reactions include the standard set of reactions - headaches, lightheadedness, dizziness, or nausea. There is such a thing as a red-flush reaction to niacin that will appear on the skin. This is rare, but also harmless. Don't confuse a harmless red-flush with an allergic reaction, which can be quite serious although they are very rare with picamilon.

Nootropic Stacks with Picamilon

Picamilon can be stacked very will with any racetam. Depending on which you choose, you can increase either the cognitive enhancement effects or the anti-anxiety effects. Combining with piracetam, for example, will enhance the cognitive benefits and motivation. However, some users have reported feeling “manic” when combining these two substances, so exercise caution. On the other hand, ampakine racetams such as aniracetam and oxiracetam will enhance picamilon's mood-boosting benefits.

Try combining picamilon with non-nootropics, such as valerian root, a European herb used to treat insomnia and chronic anxiety disorder. This is a good stack if you're interested in picamilon for its sleep-promoting benefits. Or try stacking with kava, a natural remedy used to relieve stress and make you feel calm and happy - a good choice if you want picamilon to help you through a stressful situation.

Where to Buy Picamilon

Where to get Picamilon

As of 2015, the FDA classified picamilon as a substance that does not meet the requirements of a dietary supplement and is therefore no longer permitted to be sold in the United States. However, no such restrictions have been placed on the UK or most other countries around the world. In the UK you are not asked to have a prescription drug agreement to purchase picamilon.

Closing Thoughts

Picamilon is a fantastic anti-anxiety and pro-alertness nootropic supplement. It can be good for reducing anxiety, feelings of stress and overwhelm while simultaneously increasing feelings of alertness and motivation. If you want to feel focused, relaxed, and stress-free, picamilon might be perfect for you.


Coluracetam Review

Coluracetam

Coluracetam is a subtle mood-enhancing nootropic which can also enhance working memory and creativity. It works by increasing the brain's production of acetylcholine, a molecule that acts as a neurotransmitter that affects neuroplasticity, arousal and reward, as well as alertness and memory.

As a member of the drug family “racetam”, coluracetam works well in nootropic stacks with a number of other nootropics and substances. Synthesised in 2005 by the Mitsubishi Tanabe Pharma Corporation, coluracetam was a derivative of piracetam and an attempt to create a new treatment for Alzheimer’s disease. It was later in-licensed by BrainCells Inc to investigate its potential for treating depression with very promising results. Read on for the full Coluracetam nootropic guide.

Benefits and Effects

The most profound subjective effects of coluracetam appear to be an increase in mood and, for some people, a visual vividness which makes the world look very “high definition” and colourful. It lacks the energy-boost of other racetams, which makes it work well in combination with stimulants. It's a good choice if you just want to feel better without feeling “buzzed” or “wired”.

Coluracetam effects

Depression and Anxiety

Coluracetam was found to have significant positive effects on people suffering from major depressive disorder (MDD) and generalised anxiety disorder (GAD). In brief, major depressive disorder is what most people think about when they think “depression”. It's characterised by an extended low mood and lack of motivation for normal things that persists across various activities. Many people experience MDD for brief periods of time, while others suffer through it constantly. Generalised anxiety disorder is a little different. It is characterised by excessive and uncontrollable apprehension about everyday matters.

BrainCell Inc studied coluracetam's potential to treat depression by dosing subjects with 80mg daily for three days (which is a higher dose than we would recommend, by the way). 36% of subjects scored better on a depression assessment test after two doses.

Anecdotal reports reflect these results some people feel much happier on Coluracetam, whereas others experience a far more subtle effect. In the studies, the largest effect was found on patients who didn't respond to standard antidepressant medication.

Like most things in biology, depression is a spectrum. Many of us have felt “depressed” or “anxious” without actually having “depression” or an “anxiety disorder”. You don't need to have been born with a faulty brain. Normal people can be pushed by life circumstances to certain thresholds or breaking-points.

Coluracetam seems to facilitate feelings of happiness and positivity by increasing the amount of acetylcholine in the brain. Some other racetams affect how acetylcholine is used by the brain, which might explain the energetic boost of those substances. Acetylcholine is used for a number of things, and one of them is positive emotion. It could be that by increasing the amount of acetylcholine in the brain, your brain now has the raw materials necessary to elevate your mood naturally or with natural nootropics.

Besides MDD and GAD, sufferers of SAD (seasonal affective disorder, or feeling depressed in the winter time) have reported a great effect from coluracetam. It improves your outlook on work and life without giving you a “buzz”.

Memory and Learning

Acetylcholine is known for being involved in memory and learning. Scopolamine (a drug that reduces acetylcholine) impairs your ability to acquire new information. Disrupting your supply of acetylcholine to your hippocampus results in quite devastating forgetfulness.

Coluracetam does not have such a big boost in cognition as some other nootropics, but it does have an effect and for some people it is quite pronounced. BrainCells Inc conducted a study on rats to test coluracetam's cognitive effects. The rats were given a mentally-impairing substance, followed by coluracetam and then they were tested with a Morris Water Maze. Coluracetam counteracted the effects of the neurotoxin very effectively, and impaired rats were still able to complete the maze.

We have no studies to turn to yet investigating coluracetam's effects on human cognition, but self-reports show that some people find it makes them more alert, focused, motivated, and creative, as well as improving working memory and the incorporation of new information. Some users find their mind becomes more fluid and, strangely enough, able to take a step back and look at things from a “big picture” perspective. If you experience the same effect, coluracetam might be a good nootropic to take to enhance strategy sessions, brainstorming, or planning.

Eyesight

The biggest mystery of coluracetam is its effects on our subjective experience of vision. Acetylcholine is not involved much in our visual processes, so another mechanism of action is probably at play. Regardless, a lot of users find this nootropic makes the world look in “ultra-HD”. Things look sharper, brighter and more colourful. There are few productive applications for this effect unless, perhaps, you are an artist or some other profession where aesthetic inspiration is a part of the process.

Some users also experience greater “immersion”. You know what immersion is when you've watched a movie and felt completely engrossed so that someone needs to say your name several times to get your attention. This might have a similar root cause as the effect of the world looking brighter and more vivid, although immersion is not specific to visual stimulus. For all these reasons, users also find coluracetam to enhance meditation.

How it Works

The mechanisms of action (as well as structure) appear to be very distinct from other racetam compounds like piracetam or aniracetam. It increases a process called high affinity choline uptake enhancer (or HACU for short). This means more choline enters your cholinergic neurons. Choline is an essential nutrient, related to B vitamins but not quite in the same family. Once inside a neuron, choline converted into acetylcholine (ACh), a molecule that performs many roles in the body, including as a neurotransmitter associated with positive emotion and making new memories.

By supporting high affinity choline uptake enhancer HACU coluracetam causes more choline to move into brain cells, so it's recommended you supplement with choline when taking coluracetam. It's not going to cause a strong choline deficiency, but it's still wise to provide the process with an abundance of raw material.

Coluracetam also seems to raise the activity of AMPA in the brain. AMPA acts as an excitatory neurotransmitter. That doesn't mean it will make you feel more excited but rather that your cholinergic neurons may fire better.

The effects on eyesight, however, are not well understood. Acetylcholine plays no direct part in vision. The sometimes strong effect of “HD vision” and vividness of colour, therefore, is probably achieved through a different process.

It seems that healthier cholinergic neurons are less affected by coluracetam than impaired cholinergic neurons. Rat studies showed that coluracetam can preserve high affinity choline uptake enhancer in rats that were given a neurotoxin that inhibits it. In the unimpaired rats, however, high affinity choline uptake enhancer didn't increase much. This might be why sufferers of depression have found coluracetam to be particularly powerful if they are resistant to other treatments. Depression can be caused by a huge variety of things. Perhaps some people are depressed because of a natural impairment of high affinity choline uptake enhancer, making coluracetam the only drug out there that can put their brain chemistry back into healthy working order.

Coluracetam review

Coluracetam Dosage

Users of coluracetam report an effective range of 3 to 35 mg daily. Tolerance varies greatly between people, as with any drug, so we advise you to start with a low dose and gradually increase your exposure until you find an effective amount. Tolerance of coluracetam can increase if you use it daily. If you find you need to take increasing amounts to feel an effect, consider a detox. It takes 1 to 2 weeks for your tolerance to this particular drug to return to baseline. There might also be a cross-tolerance effect with other racetams, so plan accordingly if you're stacking with or separately using nootropics such as piracetam or oxiracetam.

Side Effects

You would be a very rare case to experience side effects from coluracetam. Taken at the coluracetam dosage we recommend produces no side effects in most people. If you 'are new to nootropics you may develop a headache, and that is true of all nootropics. With coluracetam, you can minimise the chance of a newbie-headache by supplementing with choline (see below). It also appears to be completely non-addictive, lacking any way to act as a “chemical hook”. As with all things that benefit you, you might develop a habit that is then hard to break, but there is nothing in the drug itself that makes it addictive.

Nootropic Stacking

Coluracetam is an excellent addition to many nootropic stacks. It works safely with many other popular nootropics, from noopept to modafinil to piracetam. Its main effect of boosting mood pairs very well with other nootropics which focus more on energy and cognition.

L-Theanine

Combining L-Theanine and Coluracetam can dramatically improve your mood. L-Theanine is a compound found naturally in tea leaves that has a calming effect on users. It's a safe choice for most nootropic stacks and is sometimes used by people who experience some unpleasant anxiety when taking energy-increasing or focus-boosting nootropics such as modafinil or piracetam. It can often solve the anxiety problem immediately.

In addition to calming you, l-theanine can also increase your capacity to pay attention, to focus, and even to learn. Add to that the positive mood and additional learning benefits that coluracetam can produce, and you may have a very effective stack for getting you through stressful times or to work or study most effectively.

Racetams

Coluracetam works synergistically with other racetams. For example, oxiracetam is a powerful nootropic that affects a wide array of cognitive enhancing abilities, from improved memory to motivation to attention span and more, and can be used safely with coluracetam. Combining oxiracetam with coluracetam and l-theanine could give you a stack that dramatically improves your processing power while keeping you calm and happy at the same time. You could try stacking with any of the other racetams, such as pramiracetam, aniracetam, or phenylpiracetam.
Choline Supplementation

Like most racetams, coluracetam nootropic stacks well with a choline source, such as Alpha GPC or CDP choline. Since coluracetam works by converting choline to acetylcholine, increasing your choline intake gives it more raw materials to work with and might enhance the effect. The recommended doses for supplemental choline is 300 mg to 600 mg a day if you’re stacking with Alpha GPC and 250 mg daily to 750 mg a day if you’re using CDP choline.

Where to Buy Coluracetam

Coluracetam mgColuracetam Choline Uptake HACU is not easy to find. Nixest makes it simple and secure. Click “ADD TO CART” on this page and you'll be taken to a partner page where you can buy coluracetam directly from the original manufacturers. This gives you wholesale prices, making it much cheaper for you if you go through Nixest. You also enjoy automatic buyer protection and your purchase can be shipped for free anywhere in the USA, Australia, and the United Kingdom.

Closing Thoughts

We all have days when we feel low, unmotivated, and mentally foggy (brain fog). Coluracetam has profound effects for some people on working memory, mental fluidity and improved memory, and most of all it induces a state of clear-headed positivity. The mood-enhancing effect is relatively rare in the world of nootropics. Most affect cognition and motivation in a mood-neutral way. This, combined with coluracetam's unique mechanism of action in the brain, means that it makes a particularly great addition to almost any stack, allowing you to keep all the benefits of the stack and add to that a feeling of positivity and optimism. Negative mental states can lead people to make bad decisions, no matter how good their working improved memory or attention span. Plus, it feels good to feel good!

Try coluracetam first as a standalone so you know how it affects your specific biology, and use it to enhance your state and sharpen your mind for activities such as strategy sessions or interpersonal work.

Nixest is the No1 online vendor of Modafinil, Armodafinil, and other nootropics. They specialize in selling Modalert, Waklert, Artvigil, and Modvigil. They offer safe shipping and secure payment services. They can get you what you need at affordable prices and with prompt, discreet shipping. Payment methods include credit cards and Bitcoin.


Powder city supplements

What Happened to Powder City?

How does a major nootropic vendor fall?

The death of customer might do it.

In 2015, 28-year-old Colby Patrick Brennan received his first pack of tianeptine from Powder City in his home in Harris, Texas. Later that day, he was declared dead. The Harris County Institute of Forensic Sciences determined that the cause of death was tianeptine toxicity.

Colby's parents filed a lawsuit against Powder City for including inadequate instructions on the packaging. The Tianeptine allegedly arrived without any warning labels and included “entirely inadequate instructions,” according to the SE Texas Record. For this reason, Charles and Mary Brennan made the case that Powder City ought to be held accountable for the death of their son.

Tianeptine is an antidepressant that can mimic the effects of opioids at high doses. It has been used intentionally as a means to suicide before, as have true opioids. The intentions of Colby Brennan cannot be verified, however. The case was made that he tried to take an appropriate dose and merely misread the label. Powder City LLC, at the very least, left themselves open to a legal crisis by not being clearer about the potential dangers of tianeptine on their packaging.

How clear do warnings and dosage instructions need to be? Do vendors need to be as achingly explicit as the peanut-packaging companies who print “may contain nuts” on their airline snack products?

Close-up of the label on a bottle of tianeptine. This is likely to be similar to
the label Colby was presented with. Are these instructions enough?

Let us know it the comments if you think the label above is sufficient, or if there is room for improvement. As a vendor of nootropics ourselves, we care about this!

As for Powder City, the lawsuit was financially overwhelming and they closed up shop in fall of 2017, along with each powder city employee. Much of the nootropic scene lamented this event because there are few other places one can go, even online, to find such a wide selection of products for such a competitive price.

The domain and the trademark were sold, and finally we saw a Powder City LLC reopening under its new owners. However, it seems the many products on PowderCity.com now point to various affiliate sites who offer affiliate disclosure. Powder City LLC used to maintain very low prices in comparison to the rest of the market by ordering large bulk orders of their product at once and shipping them from in-house. The model currently running (with pages simply pointing to other vendors), is much more hands-off and cannot promise the same cost advantages.

Is Tianeptine a Dangerous Drug?

If this lawsuit was onto something, what's the problem with tianeptine? Is it dangerous? The answer depends on whether you treat it with the same respect you treat Paracetamol.

Paracetamol is the most commonly sold treatment for pain and general flu symptoms the world over. However, that doesn't mean it's completely safe. Far from it. For adults, the minimum acute hepatotoxic (liver-damaging) dose is 7.5g. The average Paracetamol tablet contains 500mg of the active drug, meaning that 15 tablets is considered a potentially lethal dose.

Tianeptine is not as well-studied as Paracetamol, so we don't have as much data on its toxicity. Anecdotal evidence certainly suggests that it is possible to overdose on it, but only at much greater multiples of the recommended dose as Paracetamol. There are some that analyze the affects of Alpha GPC vs CDP Choline.

On the forum Blue Light, one user posted a cautionary tale. In an attempt to battle an opioid addiction, he routinely took tianeptine at doses high enough to produce an opioid-like effect. One day he took two intravenous shots of approximately the same high levels in one day. He woke up on a stretcher. He had collapsed onto the floor, stopped breathing and stopped producing a pulse. Thankfully, his family found him quickly and paramedics were able to revive him.

His regular dosage was 300mg-400mg (24-32 times the recommended daily dose of 12.5mg). Although he doesn't specify the exact dose he took on the day he collapsed (“several hundred milligrams” + 300mg), we can assume that together was at least 50 times the recommended dose.

In another case, a 26-year-old used tianeptine to successfully commit suicide. He was found dead on his bed next to a suicide note. His post-mortem toxicology results showed 5.1mg/mL of tianeptine and 530mg/mL of alcohol in the blood. More than 300mg/dL of alcohol is considered potentially fatal, so it's not clear which substance did more damage. According to the report, “the toxicological analysis led the pathologist to rule that death was due to an intoxication caused by the suicidal ingestion of tianeptine in combination with alcohol.”

Having said all that, don't be scared to try tianeptine if you are in the market for an antidepressant. Taken responsibly at the recommended dose it is very safe. It produces as much of an effect as other antidepressants (such as imipramine, amitriptyline and fluoxetine) with far fewer negative side-effects. It is very effective against chronic anxiety and panic attacks. It has also been proven to be effective in treating Parkinson's disease and post-traumatic stress disorder. Be aware, however, that it is an addictive substance. If you are considering it, consult your medical practitioner and perhaps a clued-in psychotherapist for advice.

Is Tianeptine Legal? - According to the Food and Drug Administration

Tianeptine has been approved for sale in many countries in Europe, Latin America, and Asia, but is no longer approved in the USA. The North American patent expired and it's not commercially viable to invest in the litany of clinical trials necessary to renew its US product license. Even after approval by the food and drug administration, tianeptine can only be sold as a cheap commodity due to generic competitors. For this reason, it needs to be sourced from outside of the United States for the food and drug administration.

Tianeptine from Powder City

What else did Powder City sell?

Powder City offered a high variety of drugs, cognitive enhancers & dietary supplements besides antidepressants. They offered cognitive enhancers of function, energy, and even build muscle growth and fitness. Their total list of products reached 299 items, although some of those include the 'paraphernalia' of supplementation such as measuring equipment.

Top Sellers
Adrafinil: a compound that the body metabolises into modafinil after ingestion.
Coluracetam: a nootropic that improves mood while sharpening memory.
Cardarine: an athletic supplement that enhances fat loss while increasing endurance.
Methylene Blue: benefits mitochondria and enhances energy formation in the cells.
Noopept: a strong 'racetam' with profound effects on cognition.
Phenibut HCL: increases mood, sociability, and relaxation.
Phenylpiracetam: enhances memory, problem-solving and physical performance while reducing anxiety.
Pramiracetam: boosts memory, focus, and learning capacity.
Tianeptine: the antidepressant that got them in so much trouble!

Energy Enhancement

Energy boosting drugs and dietary supplements are very popular among bodybuilders and athletes who need that extra kick to get them through a competitive exercise routine. Powder City LLC list 64 items under this category, the most notable being Focus3D, a proprietary formula that Powder City owned. It contains TeaCrine, L-Theanine, Dicaffeine malate and Caffeine Citrate.

According to the product page, the Focus3D formula was developed by gaming enthusiasts that wanted a long-lasting yet intense energy boost. In addition to the intense stimulant effect created by the various different kinds of caffeine, the theanine in this cocktail quells anxiety and reduces the jittery nerves typically felt by people on caffeine.

Mood Enhancement

Other than tianeptine, Powder City LLC sells about 57 other products related to improving your mood as well as dietary supplements. For the chronically stressed, for example, Tongkat Ali could be a solution. Found in a plant native to Southeast Asia, Tongkat Ali has been used in herbal remedies for many generations. Not only does it improve your mood, but it also boosts your levels of testosterone for sexual health. It is also used to treat symptoms of erectile dysfunction.

Serotonin, a crucial neurochemical in the production of feelings of pride and self-worth, is produced in the body with the naturally occurring amino acid 5-Hydroxytryptophan (5-HTP). Product City sells a number of 5-HTP products. All promote positive moods and reduction of anxiety.

Building Muscle

Amongst 36 products under “Muscle Growth” the three most popular are Agmatine Sulfate Powder, D-Aspartic Acid, and Creatine Monohydrate Powder.

Agmatine Sulfate is a natural compound synthesised by the amino acid Arginine to help build muscle. By supplementing it in powder form, you can speed up its benefits, which include reducing post-workout pain as well as decrease the time it takes for your muscles to recover.

D-Aspartic Acid is also an amino acid, though it has a very different job. It regulates testosterone production and can help with sexual health. Taking it as a supplement elevates testosterone levels for about a week to 10 days. This makes it popular for athletes in the week leading up to an event where they need to perform at their peak, or build muscle.

Creatine is a highly studied supplement and is used widely by strength athletes, in part due to its broad effects on performance. Not only does it increase muscular strength, but it also enhances the regrowth of muscle tissue, reducing recovery time. In the body, creatine is used in the energy system in the form creatine phosphate. It triggers the production of cellular energy to enhance function and repair.

Sleep

Powder City lists 13 products under “sleep quality”, which includes some relaxing supplements and drugs that we have already covered such as L-theanine and 5-HTP. One we haven't mentioned is melatonin - a naturally occurring hormone that helps our bodies regulate our circadian rhythm. There is also evidence that it is used in short-term memory and improves mood in cases of seasonal affective disorder. However, it's best not to take this supplement at any time other than soon before bed unless you want to dysregulate your body clock.

Criticism and Reputation

Before the case of Colby Brennan, Powder City in York PA had a relatively good reputation in the nootropic scene. They were known for their amazingly wide variety of products and competitive prices. A few complaints of service quality still circulated, but it's hard not to have any of those at all.

They have been accused of having biased reviews. They appeared reluctant at the very least to post bad reviews on their website. However, one customer said that after trying to post a negative review, their customer support team reached out to offer a refund. That might be a way to appease that one customer, but perhaps it was short-sighted to only select positive reviews. Other users had problems with shipping, just as the “free shipping” option taking far too long to arrive.

Testing Quality

According to their About page, Powder City used a 3rd party to test their products. After they got the results back, they would run the product through additional tests. These would include high-performance liquid chromatography, a method used to make sure a product is pure and uncontaminated.

They claimed to be very thorough, taking samples from every barrel of product that they received to test. This does not completely eliminate the potential for contaminated product, but it greatly reduces the risk. It's the most we can ask of a company, as the process of testing a sample renders it useless to the consumer. As long as they test one sample from every barrel, they could be reasonably sure the rest of the barrel's contents were in a similar condition.

Competitive Pricing

Powder City York PA was the IKEA of nootropics. A huge range, and unbeatable prices. The rest of the market couldn't keep up. For example, 5g of Noopept powder cost $6.99 at Powder City. The next cheapest price was $7.99 from Nootropics Depot, and it only went up from there to $9.80 from New Star Nootropics and $11.99 from New Mind. The price difference, of course, becomes even more pronounced when you buy in larger batches, as many nootropic enthusiasts do.

Other examples include L-theanine, which Powder City sold in 30-count bottles for only $4.97 each. Other vendors retailed the same quantity of L-theanine at somewhere from $7.99 to $25.95. Their ALCAR capsules, too, sold far below the market average of about $20 at a mere $8.99.

It's no wonder there was a small panic in the nootropic community when Powder City shut down their operations.

Reaction to Powder City's Closure

At the time of their closure, many Reddit (which has a very active nootropic user base in the subreddit: /r/Nootropics) users jumped to the defence of Powder City.

One user wrote:
“I don't usually post on reddit, but I just want to say thank you to Powder City for being an amazing vendor and I'm sure many of us will miss you. They have the cheapest nootropics and they introduced me to some valuable and helpful nootropics including tianeptine.”

Another posted:
“Very sad to see you go! best of luck!”

There were many other similar comments underneath all the threads announcing the lawsuit Powder City fought or their subsequent closure.

Their absence has opened up a gap in the market. As another Reddit user wrote:
“I cannot find a good alternative to powder city”

They appeared to run on slim margins, which they made profitable by bringing popular products in-house in huge quantities before selling on amazon or to the consumer through their website. The gap they're leaving in the nootropic market represents a significant opportunity for any large nootropic vendors out there.

Conclusion

Powder City York PA, once one of the most successful nootropic vendors on the entire internet, has been tragically reduced to rubble by a lawsuit over negligent labelling. They could have been clearer about what constitutes the recommended daily dose, as well as made a greater effort to warn consumers of the potential dangers. Even still, it's a shame to see such a huge source of nootropics and other performance supplementation (that so many people relied on) go under due to one lawsuit.

One thing is for sure - Powder City's absence is felt in the nootropic community, and it remains to be seen what will step up to fill the gap.

Lastly, if you want to try tianeptine, don't be scared off by the story of Colby Brennan. We don't know how much he took, but judging by other cases of tianeptine toxicity, it must have been far above the recommended dose of 12.5mg.

Be informed, stay safe, and bring any concerns to your medical practitioner before taking any risks.


The NZT Limitless Pill

NZT-48 Limitless Pill - Is It For Real?

Imagine pulling a pill out of its case and holding it up to the light.

What you hold in your hand is the world’s most effective cognitive enhancer.

Would you be nervous?

Would your heart rate rise as you feel the little capsule descend into your system?

What could you expect?

The mainstream world woke up to nootropics in 2011 when the Hollywood blockbuster Limitless hit the screens. The public started fantasizing about what a drug like that could do in their own life.

We collectively asked one important question - is there a drug that can make you smarter?

 

What is The Limitless Pill For?

Inside his brain on NZT

In Limitless, Bradley Cooper played a depressed, washed up writer who stumbled onto a miracle drug that turned him into a superhuman genius.

He could learn Spanish by only half-listening to a language course as he jogged. He could debate on almost any topic, holding a crowd and making them laugh. He was a fountain of motivation, expertise, and confidence. Women were putty in his hands.

“Information from the odd museum show, a half-read article, some PBS documentary, it was all bubbling up in my frontal lobes, mixing itself together into a sparkling cocktail of useful information.”

What is NZT?

The miracle drug that turned Bradley’s character, Eddie Morra, from zero to hero in one gulp was NZT-48, an unlicensed, experimental neural enhancer that his old friend/drug dealer swindled from some unsavory characters.

After stealing a large stash of NZT, Eddie does what just about any of us would do. He starts popping a pill every day, using his newly found “4-point IQ” to make oodles of cash on the stock market. Unfortunately for him, the drug had some side-effects about as bad as the benefits were good.

He learns that all previous users were either sick or dead. He was about to reach the same fate if he didn’t act fast.

Is There Anything Like NZT?

NZT-48 is, of course, a fictional substance. No one has yet been able to raise a person’s base-level IQ. It seems that, for now at least, we’re stuck with the fluid intelligence we were born with.

However, if you watch Limitless again with a critical eye, you might notice a lot of the wonder-drug’s benefits came not from processing power, but from a rise in motivation, enthusiasm, and focus.

The clarity and drive NZT provided are much more achievable. And yes, we do have a drug that seems to match up. Better yet, for those that aren’t allergic, it seems to have zero side-effects!

That drug is a nootropic called modafinil.

The similarities crop up in the first act of the movie.

“What was this drug? I couldn’t stay messy on it, I hadn’t had a cigarette in 6 hours, hadn’t eaten, so - abstemious and tidy? What was this, a drug for people who wanted to be more anal retentive? I wasn’t high, I wasn’t wired, just clear. I knew what to do, and how to do it.”

The piece of dialogue above couldn’t be closer to what some modafinil users have reported.

“Perplexed, I got up, made a sandwich - and I was overcome with the urge to write an article that had been kicking around my subconscious for months. It rushed out of me in a few hours, and it was better than usual. My mood wasn’t any different; I wasn’t high. My heart wasn’t beating any faster. I was just able to glide into a state of concentration - deep, cool, effortless concentration. It was like I had opened a window in my brain and all the stuffy air had seeped out, to be replaced by a calm breeze.”

Johann Hari, talking about his first experience with modafinil.

Let me highlight a few words from the quotes above:

“I wasn’t high, I wasn’t wired, just clear. I knew what to do, and how to do it.” - Fictional NZT-48.

“I wasn’t high. My heart wasn’t beating any faster. I was just able to glide into a state of concentration - deep, cool, effortless concentration.” – Real-world modafinil.

Modafinil is rumoured to be the original inspiration for Limitless. That doesn’t surprise me in the least.

   >   Click here for our recommended Modafinil supplier.

What is The “Genius Pill”, Modafinil?

Sold under the name Provigil, modafinil was originally synthesized in 1986 as an experimental treatment for narcolepsy, a condition which causes extreme and sudden tiredness. Sufferers can fall asleep without warning at any time of the day. It was approved by the FDA in 1998. Soon after, people started noticing modafinil had a few other favorable effects.

Silicon Valley CEOs started using it to kick even more ass than normal. In the late 2000s, Provigil became known as “the entrepreneur’s drug of choice”.

The military experimented with the drug to keep soldiers awake and performing for long periods of time. One study of helicopter pilots suggested 600mg of modafinil given in 3 doses can be used to keep the pilots alert and maintain their accuracy at pre-deprivation levels for 40 hours without sleep. Such sleep deprivation would be a risky strategy for you and me, but in a war situation, it just might save your life.

Neuropsychologist Barbara Sahakian of the University of Cambridge has been studying the effects of modafinil on healthy people. We now know it works on dopamine, noradrenaline, and potentially glutamate. Her work is focused on improving the longevity of people’s minds. She’s optimistic about the promise of modafinil, but she stresses that there are no long-term studies conducted. More research is needed to fully understand this substance.

For some people, modafinil seems to provide an incredible level of mental clarity, focus, and even motivation to complete any tasks they need to get done. What’s more, many people don’t experience a crash, a come-down, or any trace of a hangover the next day! Much like CPH4, from the movie Lucy.

Bottled Motivation

Your felt motivation can be improved by a number of tactics.

  • Improving sleep quality
  • Exercising regularly
  • Clarifying the purpose of your work
  • Strengthening your social support structure
  • Defining challenging goals that get you excited
  • Dialling in your diet for maximum energy

There are a lot of things you have to get right to attain the maximum level of motivation and mental clarity your mind is capable of.

Imagine if, instead, you could cram motivation and mental clarity into a capsule and take it with your morning cup of Earl Grey.

Could it help you get your life in order? Would it make cleaning up your apartment pass by like a blurry montage? Would you enjoy the feeling of endless focus and energy for the work you have to do, or better yet, the feeling that you deeply want to do the work you have to do?

For some people, modafinil seems to be exactly that – a hit of mental drive, focus, and clarity that lasts the whole day.

“It makes you sharp as shit.”Joe Rogan

“Holy crap. Things are effortless. I got my brain back.”Dave Asprey

“The motivation for getting things done was incredible and it came like thunder from a clear sky.”Joen Rude Falsner

Will modafinil, like NZT, send you on a productivity ‘bender’ where, in the end, you stand back and survey your room, career, or life, suddenly in perfect order?

It seems possible. As Johann Hari, at the end of his short modafinil experiment, surveyed his room, he had this to say:

“As I put the tablets aside, I look out over my flat. My desk is piled high with the vast quantities of work I have pumped out. My cupboards are full of uneaten food. The whole place is freakishly clean, something I did in my spare time, without even thinking about it.”

After some consideration, he decided he wanted to play it safe and not take the nootropic on a regular basis until further research was done on the potential long-term effects.

He says he put his stash away in his bathroom cabinet with a wistful sigh. Maybe one day…

The 2nd Highest Predictor of Lifetime Success

In the first scene in the movie, Bradley’s character, Eddie, narrates the intense scene on display. He’s about to leap off his apartment balcony, and he thinks, “For a guy with a 4-digit IQ, I must have missed something, and I don’t miss much.”

Opening scene from Limitless

Alas, there is still no way to raise a person’s IQ significantly. A lot of people have tried. IQ level is the highest predictor of life success.

But it’s not the only one.

Another trait closely follows IQ in predicting someone’s success across a lifetime. And this trait seems to be affected by Modafinil just as much as the fictional NZT.

The 2nd success trait is conscientiousness.

Conscientious people are good at planning. They follow a schedule. They get things done fast. They keep things tidy. They don’t suffer fools gladly and tend not to invite distractions from their work.

Conscientiousness fragments into two aspects: industriousness and orderliness.

Industriousness relates to work ethic. Doing what you say you’ll do. Working efficiently. Working long hours. Being productive without having to force yourself to be.

Working stocks on NZT-48

Orderliness is a tidiness trait. Orderly people like everything to be in its place, and find tremendous satisfaction in tidying up and organising.

Cleaning whilst on NZT

There are no studies yet linking modafinil and conscientiousness. Officially, there is no pharmacological intervention that affects this enviable personality trait. However, science is often slow to catch up to the explorers, and self-reports of modafinil note large increases in the following:

  • Focus.
  • Interest in work.
  • Disinterest in procrastination.
  • Irritation at distraction.
  • Eagerness to get tasks done as soon as possible.
  • Motivation to work.
  • Clear-headedness.

“By the time my editor returned to his desk, it was done. "Already?" my boss asked with his eyes wide open. I nodded casually, as if it was completely normal for me to finish my assignments early.”

Sebastián Serrano, writer for Vice.

It seems that modafinil raises one’s level of industriousness above your natural baseline. It seems to have a smaller effect on orderliness.

“Don't sit around and do nothing. It is very uncomfortable to do so, as if your mind is trying to push your body physically into doing something.”

– Helpful Reddit ‘trip report’ for modafinil.

At the very least, modafinil gets you up and moving. TV and other entertainment are less appealing when you’re on it. You could easily find yourself entering a swift montage of cleaning up your pigsty room.

  >   Try a sample pack of Modafinil today >>

For those who find modafinil fueling their conscientious side like this, it could give them a genuine advantage over their baseline self. If you don’t like the temperament God gave you, and you wish you could focus for longer, think more clearly, and work faster and longer… it would seem we have a pill for that.

Productivity increase and boost on NZT-48

Safety Concerns for Modafinil

People vary tremendously in their reactions to almost all drugs. You might know someone who bounces off the walls after one espresso. Another friend might be able to pound them all day without getting a real “buzz”. Some of that will be explained by building up a tolerance, but not all. People are built quite differently.

The diversity in reactions is no different with nootropics. If you’re considering trying modafinil, or any other nootropic, bare this in mind. Your results may vary.

Some people find modafinil to be like a miracle drug. It allows them to perform at their very best every day they take it without addiction, side-effects, or even a come-down. Could anything be better?

Others, however, aren’t so lucky. Tim Ferriss, for example, reports getting bad migraines on modafinil. Reporter Benjamin Zand took some and filmed his experience for the BBC. He developed a little puffy spot on his arm and leg, as well as slight nausea and headache. Richard of Improvement Pill found that he had an allergic reaction to modafinil, involving very itchy bumps and even blisters. If you’re on modafinil and you notice an unusual bump or rash, stop taking it immediately and get checked out by a doctor.

If you have Stevens-Johnson Syndrome, avoid modafinil altogether. For you, it can trigger a severe rash. However, SJS affects only about 1 in 200,000 people, and it’s triggered by a large variety of drugs, including some antibiotics, analgesics, cold medication, and many more. If you have SJS, you probably already know about it. If you have any doubt, talk to your doctor before trying modafinil.

The effective dosage also changes a lot from person to person. Some people take large 600mg doses (three standard pills). Others find even one pill overwhelming, and a mere 50mg dose is enough to put them in the zone without any negative side-effect.

In Summary: If you don’t have Stevens-Johnson Syndrome, go ahead and try modafinil - but be smart about it. Start with a 50mg dose and work up to a higher dose if you want. Stay mindful of how you feel, and stop if you experience any negative side-effects like rashes or headaches.

Is Modafinil Legal?

In the UK, modafinil is a prescription medication. This means that it’s not illegal to buy it for yourself, but it is illegal to sell it without a prescription. If you buy online, then, you can get around the legality issue.

There are two official suppliers of modafinil – Sun Pharma and HAB Pharma. If you source from these companies, which you can do here via Nixest, you’ll get what you pay for (and it’ll be above board).

Alternatives

You’ll find a number of alternative nootropic ‘stacks’ on the market today which come under the category of ‘supplement’, rather than a prescription drug. They cannot claim the same strength of effect that modafinil boasts, but they can still significantly boost your mental power and motivation.

The main benefit about most nootropic stacks is they are made of natural ingredients that we know a lot more about than modafinil, which is a synthetic substance and relatively young.

CILTEP

Recommended by a world series poker champion, a biohacking entrepreneur, and a grand master of memory, CILTEP has a great reputation (and has a free trial) in the world of nootropics. It’s open-source ingredient list consists of only natural products and doesn’t affect levels of neurotransmitters. Modafinil, by contrast, increases dopamine levels in the brain, among other things, and as such, some people worry about becoming reliant. In their FAQ, CILTEP claims the effects of the product are “time seems to slow, distractions fade away (increased focus), and you have a strong desire to learn/read/work. The more mentally demanding the task, the more CILTEP shines.”

MASTERMIND by Apex-Mind

Another favourite nootropic stack of ours is MASTERMIND. Also made from all-natural ingredients, Apex-Mind’s flagship product can help raise your motivation levels, enhance your ability to focus, and even allow you to go on adventures in vivid lucid dream landscapes. The fact that none of the ingredients are synthetic make Mastermind quite safe.

  >  Click here for an exclusive free trial.

If you suffer from a little brain fog or mid-afternoon slump, CILTEP or Mastermind might be enough to lift you into high productivity without any risk of side-effects.

Is Modafinil For You?

If you’re a knowledge worker, writer, entrepreneur, or you otherwise rely on your mind for your livelihood, modafinil might give you an edge over your competition that you’ve never had before. As long as you’re not suffering from Stevens-Johnson Syndrome, trying modafinil is relatively safe. As we’ve said, be aware of your body when you take it, and get off it if you experience headaches or any signs of an allergic reaction.

If you’re one of the lucky many that experience a boost in motivation and concentration without any side-effects at all, the only problem you’ll face is whether to tell your coworkers why your output has suddenly hockey-sticked!

To take the leap, we recommend trying Modalert – 200mg tablets produced by Sun Pharma.

Get in touch. We’d love to hear about your experience!


Modafinil Cat Review Closed Down

Modafinilcat Review, Why It Closed & The Best Alternative

Modafinilcat Review, Before It Closed

It was a sad moment for many Nootropic lovers when the ModafinilCat online pharmacy was closed down. My attachment to modafinil cat began when I first ordered from them. I have to say their customer service was one of the best that I have seen from an online shop. My questions and inquiries were immediately answered by the customer care people. For that reason, I kept going back from time to time.

The other advantage is that modafinil cat had all the popular Modafinil and Armodafinil brands; Waklert, Modvigil, Modalert and Artvigil. The other advantage is that modafinil cat ships (used to ship).

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The other advantage is that modafinil cat had all the popular Modafinil and Armodafinil brands; Waklert, Modvigil, Modalert and Artvigil. The other advantage is that modafinil cat ships (used to ship) all over the world free of charge, regardless of where you are. They also had a full refund policy that means you are guaranteed to get your money back if you don’t like your order or when it hasn’t met your expectation.

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This might help to lift your spirits that may have been dampened by the Modafinilcat closure; Nootropic users were not left without an option by the closure of modafinil cat. There are many other places you can order your modafinil tablets such as Nixest. Before I give my thanks to modafinil cat for their good service over the year, I would like to take an in-depth look at what it used to be. Here I will give a detailed view of what the site used to be and how placing modafinil cat orders works.

Complete Modafinilcat review

It is no surprise that many people remain in the dark about modafinil cat. Fast & Fluffy modafinil online pharmacy as they used to refer to itself was perhaps the most popular modafinil vendor in its heyday. One of the reasons why modafinil cat remained hidden (at least its mode of operation) is that they often went around the rules to make sure that they delivered modafinil to the people around the globe.
Although the online pharmacy claimed to have a base on Cat Island in the Bahamas, we discovered that they operate in India and China. You have to remember that modafinil tablets are manufactured in India amongst other places, and the bills are processed in China. This may give rise to disconcerting questions: is it legal and safe to buy modafinil from modafinil cat?

Bringing modafinil to the masses

The increased interest in performance-enhancing drugs such as Modafinil has led many people to ask; where can I get it? Modafinil and its analog Armodafinil have become the overwhelming favorite for many individuals looking for cognitive enhancement. Many of us have grappled with the question about where to source these pills.
Unsure of the legitimate sources, some have resorted to ordering Modafinil from questionable online sellers only to burn their fingers. But why would you take a gamble with an unrecognized vendor when you have a trusted and popular alternative like Nixest? Modafinilcat was one of the most trusted vendors for buying Modafinil in the UK and Modafinil to Australia, now this has switched to yours truly, Nixest.

Purpose

Before we delve deeper into Modafinilcat, it is important to consider why modafinil is such a big deal. Let’s be honest; you must have heard of modafinil, unless if you have been holed up in a cave on a remote island away from modernity. Students and working professionals have for some time now regarded modafinil as a substance you can’t do without if you are looking to improve performance and productivity.
To make it clearer, modafinil gives someone a distinct edge in almost all activities that engage in. This enhanced ability using this in every substance that you may lay your hands on. However, this great miraculous powers of modafinil have some restrictions, modafinil can’t be bought from your everyday Nootropic-selling websites such as GNC and Amazon.
In fact, Modafinil and armodafinil are classified as schedule 4 drugs in some countries such as Australia and USA which means that you can only get them legally by prescription. Thus, you have to rely on various online vendors if you want to use modafinil for off-label reasons. Modafinil cat had cut a niche for itself as one of the best vendors, and that is part of the reason why we have decided to cover it here.

Modafinil cat products

Modafinil cat stocks generic Modafinil and Armodafinil tablets. That means that all the drugs that they sell have the same active ingredients as the more popular and expensive brands such as Nuvigil and Provigil (both reviewed here). Customers are spoilt for choice; they can either buy products made by HAB Pharmaceuticals or Sun Pharmaceuticals products. It is important to note that both of these manufacturers are Indian-based.
As it is with other companies’ products; modafinil tablets come in 200mg doses while Armodafinil ones come in 150mg doses. You will find that there is much difference in these tablets but if you are not sure which company to side with, try Sun Pharmaceuticals. For the simple reason that they have been in this market for much longer and have earned a good name globally for producing quality drugs.
They also have well-outlined information and answers for those who may have questions about the generic tablets to buy. Sun Pharma products such as Modalert and Modvigil are considered more potent and expensive than the HAB Pharma products; Waklert and Artvigil. It is also important to note that Armodafinil is more potent and has a longer half-life than modafinil. It is thought that Armodafinil is as much as 1.5 times more potent than modafinil. No wonder, 150 mg of Armodafinil is considered enough to give you desired effects compared to 200mg of modafinil to get the same effects.
Customers grapple with a lot more than just choosing between modafinil or Armodafinil and HAB or Sun Pharmaceuticals; they are also expected to decide how many drugs to purchase at once. Modafinil cat sells their drugs in this quantities: 40, 80,100,200 and 300 mg. You are guaranteed to save a few buck if you chose to make larger orders. For instance, if you buy 40 pills of Sun Pharma’s Modalert, you will pay around $ 2 per pill, but the cost would plummet to $1.79 per pill if you buy around 80 pills at once.
Let’s have a look at some of the products offered by Modafinil cat

See Also: CPH4 – Can I Buy The Drug From The Lucy movie?

Modvigil review

Modvigil 200 TabletsModvigil is considered by many to be an ideal modafinil generic. Users have reported increased alertness and wakefulness by using this drug. It is manufactured by HAB Pharmaceuticals that are known the world over for its quality products. It is used for the treatment of sleep disorders such as obstructive sleep apnea, narcolepsy, and shift work sleep disorder.
Ingesting just one Modvigil tablet can help to remain productive for much longer because you wouldn’t get an iota of sleep until your desk is completely cleared. The mistake that many people make is to assume that you have to have a sleep disorder to use Modvigil. But that shouldn’t be the case, online studies and reviews have shown that as much as 90% of all modafinil sales are for off-license purposes. In fact, 1 in 5 university students in the UK is reported to have used modafinil for cognitive enhancement at some stage.
Affordability is one reason why many students are abandoning other generics for Modvigil. For as little as $0.8 to around $ 2 you can get one 200 mg tablet. What is more, you can get a discount when buying from most vendors such as Nixest.

Modalert review

Modalert Available at NixestModalert is another progressive modafinil generic in the mold of Modvigil. The only difference is that Modalert is considered most potent and that is why it is the most popular modafinil drug. Modalert just like other modafinil brands is used to treat conditions that lead to sleep disorders such as sleep apnea and narcolepsy. Modalert is manufactured by Sun Pharmaceuticals based in India, but it has a worldwide reach thanks to online pharmacies. Modalert is the best drug if you want a drug that gives you maximum results at a short time.

 

Waklert reviews

Waklert Available Online At NixestIf modafinil brands are good for you, be sure will love Waklert because it is stronger than any modafinil drug you can think of. Waklert is an Armodafinil generic which is considered an improvement on modafinil. Although Modafinil and Armodafinil tend to be similar in their effects they do have differences in their makeup. Modafinil has both the left and right-handed enantiomers also known as the ‘R’ and the ‘S’ while Armodafinil has only the active ‘R’ enantiomer.
That is what makes Armodafinil more powerful and efficient than modafinil ones. No wonder, you need 200mg of Modvigil or Modalert to get desired effects, but only 150 mg of Waklert can do the trick. The other advantage is the elongated half-life of Waklert; 12-15 hours compared to 6-8 hours that you can get from modafinil.

Artvigil review

Artvigil at NixestArtvigil is manufactured by HAB Pharmaceuticals just like Modvigil. It gained popularity after Sun Pharmaceuticals temporarily halted the production of Waklert. It is a prescription drug that has been approved by FDA in the USA for the treatment of sleep disorders. It meets both the European and American quality and safety standards. Artvigil is an Armodafinil generic, so the recommended dosage is 150 mg per day.

Modalert vs. Provigil

Modalert and Provigil are essentially one and the same drug. They are both modafinil generics and have the same active ingredient. Both Modalert and Provigil have limited habit-forming potential. They are both classified as schedule IV controlled substance meaning you can only get them by prescription.
The difference is that while Provigil is manufactured by the Pennsylvania-based Cephalon, Modalert is made by the Indian-based Sun Pharma. But all these brands are available on the US market. If you can’t choose between the two, the price might be the deal maker. Look at the affordability of each drug and then make your pick.

 

Modafinilcat legal:

Could purchasing drugs from modafinil cat leave you with the need for a lawyer? Many people would want to test the waters but are not sure what might come their way if they choose to go this route. Purchasing prescription drug from an online pharmacy might seem like shady deal, but that is not the case with modafinil and Armodafinil drugs.
Modafinil is a schedule IV drug in the USA and many countries in the west which means they have lesser restrictions than commonly abused drugs such as Xanax and Adderall. That is why your modafinil purchase will not be seized by an official, and it is even much better if you buy online. There is no need to look over your shoulders as you do that because it is much harder for authorities to know who made the order. Has anyone ever been prosecuted for buying modafinil from Modafinilcat? Not at all, on the contrary, modafinil cat might be the ideal place to buy modafinil that will give you value for your money.
Ordering and shipping steps
Modafinil cat has a catchy slogan, ‘order like it’s like Amazon’ is good enough especially for newcomers to the modafinil scene. Some people think that ordering from modafinil cat is a long and convoluted process, but that is not the case. It is simple as cake; all you need to do is to identify the brand and quantity that you want then you will be directed to check out.
Here you can pay for your order using a variety of forms such as credit or bitcoin if you want some anonymity. The next stage is to provide your personal information such as name, email, shipping address. You will get a tracking number to help you keep tabs on your order that will get to you between 3 to 35 years.
For those who might be worried that their order might be lost in the crowd of many others, you should rest easy. There is a very limited chance of that happening. But if you encounter complications with your order, modafinil cat will either refund you or re-ship. But they tend to do the latter much more unless if you specifically request a refund.
While it is true that modafinil cat closed to the chagrin of many users, there are many other online pharmacies and vendors such as Modup, Afinilexpress, and Nixest. They are all reliable places where you can Modalert and other modafinil products. Modup is the only exception because it offers only Modvigil while Afinilexpress and Nixest have all the four brands.

Now let us look at these vendors in details

Nixest review
Nixest.com is the closest and perhaps the best thing out there comparable to the wound up Modafinil cat. Nixest has endeared itself to modafinil users all over the globe and earned many shout outs online in return. It has established itself as a reliable, fast and accommodating online pharmacy.
No wonder, it has consistently been rated as one of the best, and we would want to analyze that and come to a definite conclusion. Customers’ and users’ reviews as written on various online platforms is one way to know how the product has been received by those it is meant for. Having said that, one user’s account stood out while checking for feedback online. He was pleasantly surprised that the order came soon than expected.
He placed the order and hoped that it would come within a week or even much more prolonged period, but the order was delivered the next day against all hopes. He learned about this by following his order via email using a tracking number that he had been given after placing the order. He has no qualms about recommending Nixest to another buyer as one of the best modafinil online vendors.
Customer service is another reason why some people are switching to Nixest as their main source of modafinil tablets. That includes the ordering process, shipping process and the response to questions. Besides, Nixest can offer as much as 15% discount on their products to make them affordable people of all levels of income.

Ease of ordering

It is very much easy to order from Nixest. Many people know that the online pharmacy stocks Modalert but they are very many other brands that might give you the effects that you need. For instance, Waklert is the go-to drug for people who need some heavy duty focus and concentration. Select the type of brand and the quantity that you want then head straight to cart.
You can order a sample pack if you are not sure which brand to buy. A sample pack has ten pills of each type of modafinil to help you settle on one after trying out several options. That is how simple it is to place your modafinil order on Nixest.com.

Secure Checkout

For those of you who look for coupons before making the purchasing decision then you are the right place. At Nixest.com you will fill your order in the same way as one buying on popular sites such as Amazon or eBay.
What is more? You can buy with Bitcoin if you want to remain anonymous but Credit cards also work which is also the most preferred mode of payment for the majority of customers.
Nevertheless, your personal information is secure regardless of the payment option that you choose. The checkout is straight forward and you are guaranteed of getting your money back should your order run into problems.

Refund policy

Here is the cherry on top; nixest.com has a customer-friendly refund policy just like modafinil cat. Nixest guarantees to refund you every penny if you order is lost somewhere in transit. There is also the option of having a similar order shipped for those who don’t want a refund

Your order is on the way

Take a seat and wait if you order has gone through without any trouble. You will receive a confirmation email that will also lead you to a thank you page. This is as great as you can get; most companies don’t bother to thank you after you have parted with your money and placed the order.
The maximum most businesses can do is to send you an order page, and that might be just about it. But Nixest would direct to the thank you page that will automatically lead to the FAQ section that will answer any lingering question that you might have left in your head.
You will receive an email notifying you that your order is on the way. Nixest has an excellent tracking system that will help you to follow your order until is delivered to you. You will get a tracking code in the email that you will receive after placing the order.
So if you are looking for the safest online shop to buy modafinil, we advise you to try Nixest.com. They say the proof is in the pudding; check out a few reviews on Reddit and other website to find out why people are waxing lyrical about Nixest.


Provigil / Modafinil and Alcohol

We all have some nights where we just want to kick back on the couch after a hard day’s work with a beer or two. Usually, you shouldn’t think too much about having your favourite drink, but if you use nootropics, then it might be necessary to get a second opinion. Are there any adverse side effects when you mix Modafinil with alcohol?

Many drugs recommend taking a temporary break from drinking for fear an adverse reaction between the two chemicals. As expected, many people don’t take the advice seriously. It is just the doctor’s way of playing safe; they might reason. Believing that no actual harm can come from downing a few bottles while on medication.   However, missing drugs and alcohol can have adverse effects, and the warning should be taken to heart.

Given Modafinil’s popularity as a smart drug of choice among university students, it shouldn’t come as no surprise that a few cases have been reported of mixing the two substances.

Although there isn’t any specific contraindication, it is considered unwise to use alcohol while still on Modafinil.  Any random search in nootropics forums would bring lots of experiences from various people about how using alcohol with Modafinil affects them. I can guarantee that most would talk about how it increases their tolerance to the drug.   Mixing the two substances makes one extremely inebriated.

Click here for our recommended Modafinil Supplier

 Glutamate and GABA

But what’s the science behind this?  Glutamate and GABA (gamma-amino butyric acid), the brain’s neurotransmitters that create the link between alcohol and Modafinil.   GABA is an inhibitory transmitter that is responsible for various functions such as regulating anxiety while Glutamate is an excitatory neurotransmitter that controls learning and memory.

Modafinil is a GABA antagonist which means that it prevents the production of this transmitter, thus shutting out anxiety.  On the other hand, Modafinil is also an activator of glutamate which means it triggers the increase in production of glutamate. So Modafinil inhibits the production of GABA while enhancing the production of glutamate. A complete opposite of what alcohol does.

Alcohol activates the GABA neurotransmitters while inhibiting the glutamate.  It is important to understand that GABA is the neurotransmitters that are responsible for sedation and other calming effects. It also helps to maintain a tricky balance with other excitatory neurotransmitters such as glutamate. Alcohol is a spoiler of the party; it increases GABA to out-of-control proportions without increasing excitatory transmitters such as glutamate, epinephrine, and acetylcholine.  Resulting in extreme mood swings. No wonder, people become such an emotional wreck once they take in booze.

However, as most of you might know it is possible to build a tolerance to alcohol pretty quickly.   To the extent that it no longer has any meaningful impact on you regardless of how much you take. This can be dangerous; you can black out because of being too intoxicated unawares.

This is due to the increased release of the GABA neurons which makes make you less sensitive to alcohol, and reduced release of the glutamate neurons was making you more responsive to the agonist such as Modafinil.

However, taking a drink rocks the boat by upsetting the tricky balance that has been in existence.  It turns the built up tolerance to alcohol on its head by creating an entirely opposite reaction than what the body is accustomed to by taking in alcohol.

So in a nutshell, Modafinil destroys the tolerance to alcohol that you had built up over the years. It takes you back to the point when you began taking a drink. Thus, you will get drunk quicker when you take the two substances

For instance, someone who gets drunk after 3-4 beers would feel the effect of alcohol just after one beer with Modafinil. However, subsequent beers might lose their effect.  Which means that the more the drinks, the less the effect.    Thus, you have to watch out because you can get drunk without feeling or noticing.    Then you will have the morning sickness and hangovers to contend with the next day.    The best advice would be, to get clearance from your doctor if you can’t give up the booze even while using Modafinil. Different people tend to react in a variety of ways to booze.  So you have to listen to your body and stop when you feel you can’t keep with your insatiable appetite.

Dangers of mixing alcohol with Modafinil

As explained above, Modafinil and alcohol aren’t the best of bedfellows.  Thus, combining the two isn’t the best idea, one can amplify the other’s adverse side effects.  Remember that both Modafinil and alcohol have quick dehydrating effects on the body. Which means without enough drinking water, the hangovers would be so brutal the next day.

There is also the danger of overheating if you are dancing, running or in hot and dry climate.  The result of this can be dangerous. Hence, due diligence should be taken to ensure you remain hydrated while drinking or using Modafinil.    Combining alcohol and Modafinil will get your drunker than you expected. One of the reasons for this is that Modafinil reduces your appetite, you feel the effects of alcohol faster if you are drinking on an empty stomach.

Another reason is that Modafinil fights the depressant effects of alcohol. Hence you might not feel drunk as you are, even if you can barely walk.    As a result, you will drink more assuming that everything is all good. But when the effect of Modafinil wears off, there can be disastrous results.   For instance, one can black out due to excessive intoxication.

Drinking alcohol on Modafinil

Let us be honest; some people will keep taking their beer with Modafinil regardless of the contraindications they come across.  So how do you use Modafinil if you are going to drink?  The first thing you need to know is, taking due caution is in your best interest. The information below might help.

Don’t forget to eat

Modafinil like most stimulants has the tendency of suppressing your appetite, but you have to learn to turn a blind eye so that and eat. Eat sufficiently and regularly even if your appetite can’t let you.  Unless if you want to lose weight, but even so, that is not the best way to take.   There is a big difference between starvation and diet. Not eating well during the day will have a massive carry-forward impact on your evening or even the next day.  Not eating also reduces Modafinil ability to improve your performance.

It is important to note that your brain burns a significant number of calories and using Modafinil fuels that consumption.  Make sure you keep track of your eating habits so that you follow them strictly when using Modafinil. Some ideas to help you; learn to snack at work or set a reminder if you must.  The bottom line, better eating ensures that your body is in good shape to give your best results with Modafinil

Drink water

Some people complain of headaches when using Modafinil, but it all boils down to how much water they are taking. Modafinil is one of the leading causes of dehydration, but alcohol will dehydrate you faster than Modafinil. Take enough water, more than you would normally do if you ever combine the two. The thing is, Modafinil like all the other stimulants is a diuretic. Hence, you need to drink enough water, extra trips to the bathroom, notwithstanding.  Just keep replenishing all the water that you lose.

Be sure your body will be passing a lot of water if you combine Modafinil with alcohol. Keep an eye on how much booze you take so that you don’t drink in excess.      You may need to add some electrolytes to your water as well.  It doesn’t mean you need a dozen bottles of Gatorade.   But some pinch of salt added to your water might just be enough to keep well hydrated throughout the day.

You may want to keep track of how much water you drink on any given day. Then consider increasing the amount when you take Modafinil with alcohol. If you typically take 2-3 bottles of water on a working day, consider taking 3-5 when you were using Modafinil. You will be head-ache free.  So often we get so engrossed at work that we don’t pay attention to our body needs, so set a reminder on your phone. It doesn’t have to be a big deal, just make sure your body is getting enough water.

Conclusion

Although Modafinil may enable you to go past your alcohol limits, the results can be disastrous.   When it comes to using drugs and alcohol, ‘safety first’ should be your mantra. Don’t take Modafinil so that you can party the whole night as you guzzle booze.   If you have taken Modafinil in the morning or later in the evening (although not recommended), know that it takes up to 12 hours for it to completely leave your body.

Always remember that alcohol and Modafinil are not the perfect mixes. If you want to get the most out of Modalert, don’t follow it up with a dumb drink. There are a time and place for both but not at the same time. With that in mind, combining the two substances isn’t lethal but why risk to outweigh the little results that can help you in the long run?

 

https://www.youtube.com/watch?v=5oQQUDRDis8


Modafinil and Caffeine

Anyone who owns a car knows that there are two ways of getting more horsepower out of the car engine. You can either supercharge or turbocharge. Both methods can bring your vehicle’s power to higher levels than you can imagine. But can the two be combined to get more horses out of the engine without wrecking it?  That is what we are set to find out with caffeine and Modafinil. Obviously, they are not the same as super or turbo chargers but let’s just use this analogy for now.   Before we think of mixing them, we need to know what they bring to the table as stand-alone cognition enhancers.

Let start with Modafinil

Modafinil

Modafinil is the eugeroic prescription drug that is approved by the FDA to cure various kinds of sleep disorders. It is manufactured and distributed by Cephalon and sold under the brand name Provigil

. It has crafted a reputation as a smart drug of choice for many although its use as Nootropic is off-label.  Modafinil is known to boost brain power, enhance performance and ease fatigue.  As a result, many college students and academics are using it to increase their intellectual performance and productivity.  Modafinil is a wakefulness-promoting agent that is used to increase focus and rid one of sleepiness that gets in the way during a working day.

No wonder, students have moved with speed to make Modafinil their friend in need. Studies show that 1 in 5 students use Modafinil, mainly to get through exams.   Modafinil gets the best out of the brain especially when there is so much to take in when exams are knocking on the door.  It improves focus, motivation and boosts energy levels to stay up and pour over volumes of books.  It has the same stimulating effect of caffeine, but it is much stronger.

Just in case you are wondering, Modafinil is safe to use. It has had no recorded deaths in the 17 years it has been in use. The side effects are very mild such as nausea, dizziness, vomiting, and headache. But there is no need for alarm because there is nothing severe. But it would be good to get clearance of a medical professional before you begin taking the drug.

Caffeine

Caffeine has been used as a stimulant for centuries now. Widely considered as the most popular Nootropic on earth today. Drinking coffee gained notoriety and popularity in the 17th century England which led to a rise of many coffee shops also known as ‘penny universities.'  All you needed was a dime to grab a cup of coffee and have highbrow conversations with other people in a coffee shop.  Coffee is possibly the most common Nootropic, and there is, for a reason; it is ubiquitous and safe to use.

Some of the main benefits include; prevention of Parkinson’s diseases in some cases. It is also used as an antioxidant to repair damage to neurons. Caffeine is also widely considered good for the heart, and it also helps in prevention of liver cancer.

However, you need to be wary because of caffeine use increases anxiety, leads to mood swings and can give one a coffee breath. Nothing severe as far your health in concerned

Interaction

Modafinil is great on its own but combining with something else gives it an extra edge. In a process is known as stacking.  Modafinil and caffeine are one of the most popular Modafinil stacks. The two have distinct pharmacological differences, but they are closely associated together because of their positive effects on the users.  The only difference is that while caffeine has a shorter half-life, Modafinil has a relatively longer duration. Modafinil is also known to amplify the effects of caffeine.

See Also: ModafinilCat Closed Down, Here's The Best Alternative

Caffeine is cheap and readily available stimulant while Modafinil requires a doctor’s prescription, but they are both used for cognitive enhancement and boosting wakefulness. The question worth asking is, how they interact?

Modafinil like caffeine works by altering the chemicals in the brain that regulate sleep and wakefulness. Thus, there is no reason to believe that caffeine interacts negatively with Modafinil.  But you can still ask your doctor for clearance if you have any questions about combining the two.  Given that both caffeine and Modafinil are wakefulness promoting agents, combining them would mean enhanced impact on the user.

Like when you combine super and turbocharge. Great at is sounds, it might wreck your engine if you rush into it with your eyes closed.  Combining Modafinil and caffeine can leave you open to panic attacks and anxiety. Therefore, you need to be wary.  For instance, if you usually take 3 cups of coffee a day, you can cut down to one cup alongside Modafinil and see how it goes.

Those who use caffeine as a pre-work supplement would know that its effect wears off pretty quickly. You can’t rely on coffee to keep you energized for the rest of the day. Also, the body tends to build tolerance for coffee very fast. That’s why some people have to take 10 cups a day to get any meaningful energy boost.  The effects become so short-lived, once your body has built tolerance for coffee. Therefore, a more potent stimulant is what you need to perk you up.

From experience, I have learned that there are variations in how they interact from one person to another.  Modafinil kicks out all the feeling of drowsiness and fatigue that affects many sedentary people. On the other hand, caffeine boosts the thinking speed.

Although both of them seem to work in a complimentary way, my choice would be Modafinil if I was asked to choose between the two.   Modafinil is a cognitive booster per excellence; coffee doesn't even come close. So what the heck is the point of coffee when you can get Modafinil?  Modafinil is more potent, more effective and it does have a jittery feeling like coffee. However, the cost might be slightly on the upper side compared to coffee.

As many of you already know, you need to be sure about the timing and dosage if you want to get the most out of stacked Nootropic.   I would advise that you take your Modafinil in the morning as always and then your cup of coffee later in the morning or after lunch.  The caffeine shot will get your internal turbo spooling up when you need it the most.  Taking the two at the same time may give you a raw deal rather than the much-needed potency that you expect from tinkering with the two stimulants.

However, don’t over boost your turbo because it can damage the engine.   The thought of getting a high boost can be tempting.  But you need to watch out for the addiction and the feel of power that comes with it. Similarly, stacking nootropics can be dangerous. Some people guzzle gallons of coffee with Modafinil because of the power that they get but they don’t think of the harmful consequences.   Having too many coffees with Modafinil can lead to over-simulation. Causing a great feeling of anxiety than what you are used to. You need to find the right balance between the two for seamless interaction.

Caffeine and Modafinil have a synergistic effect, so just take the recommended dosage, and you will get the energy boost you require to complete your tasks.   Don’t take this combination if you are not busy because it can drive you nuts.  The high increase from this combination needs to be channelled into a meaningful activity like clearing our desk of all pending projects.

Side effects

Is there any side effect of taking caffeine together with Modafinil? The short answer is yes! Taking caffeine and Modafinil can significantly enhance a feeling of wakefulness and cognitive abilities, but there are some considerable drawbacks.  This combination can cause a substantial amount of discomfort.

Taking caffeine and Modafinil within few hours of each other can lead to side effects such as headaches, irritability, agitation, jitteriness and a feeling of tightness in the chest.  Although none of these side effects are life threatening or able to cause impairment, they can be pretty uncomfortable and unpleasant.  It is in your best interest to exercise caution when taking this combination.

That doesn’t mean you have to cut off caffeine from your system completely.  If you are a caffeine addict, you know how important your daily dose is for normal functioning.   While   Modafinil is powerful enough to give you the much-needed energy boost on its own, your body still needs the daily caffeine ritual normal operation.  For this reason, any abrupt stop of caffeine consumption can lead to severe withdrawal symptoms.

However, you may have to cut down on the amount of caffeine that you take. Too much of coffee can heighten the diuretic effect of Modafinil leading to dehydration.  The combination can be overwhelming to most people causing undesirable effects such as feelings of anxiety and jitteriness.  Many individuals who have used this combination quickly find out that it can be a hyperactive mess in the beginning. But with experience and experiment they tend to find what works best for them.

 

 

 

 

 

 

 

 

 

 

 

 

 

 


The Future of Neuroenhancement: Modafinil?

Did you know that a normal human being only accesses about 20% of their brain power?  Smart drugs have the ability to boost brain power so that one can do much more.  With what one already has; it is like getting the brain to perform to it true potential.  So people, is Modafinil cracked up to be what people say?  Tell me of any drug that gives you great pleasure as you work and lets you do so much, that you wouldn’t be without it and I would agree that the accolades received are justifiable.

Human life has gone through various phases over the years with every evolutionary step  characterized by   scientific and technological advances.  Neuroehancement is the new in-thing  that seeks to boost and stretch natural human abilities. Smart drugs such as Modafinil have captured the attention and imagination of many people because of the immense possibilities that they promise. Most people would want to be mentally sharp and to clear the cob webs in their brain.  It is not like   enhancing our natural human abilities is something entirely new.

The human society invented   the wheel for movement, the compass for navigation and the wire for communication. Improving our brain power and the way it functions is something we all should agree on if we want to get ahead. Who doesn’t want to do much more than they are presently able to do? It is a no brainer really.  Considering that our minds tend to suffer from constant fatigue and we have to recharge with sleep and rest before getting back to work.  But the smart pill changes the long held truth about brain power on its head. By unleashing potential and ability that you didn’t know existed.

But imagine what your brain would do with a smart pill that promises much more than a sharper mind. Modafinil can increase wakefulness, cure sleep disorders and increase general wellbeing. The good thing is you don’t have to be sick of any condition to use this drug.  You just need to be ambitious enough. If you want to do more and achieve   more with little effort then you   need the potent power of Modafinil to get you there.  Whether you are a student sitting exams who want to push your mind to the edge or a writer who has loads of stuff to be written, one smart pill is all you need to get you firing on all cylinders.

Modafinil, licensed by the American Food and Drug Administration (FDA) is the first of its kind. The drug has earned its renown due to its ability to improve the cognitive abilities of perfectly normal individuals. Using the drug like getting a push forward in our human evolution cycle.  It expands our normal brain functioning. The safety of the stimulant drug has been tested and confirmed over a long period of time. Modafinil has passed all sorts of necessary safety checks to ensure that is good for human use. The drug has proven record of helping people with sleep disorders stay awake. Very impressive results have been reported in individuals with neuropsychiatric disease; their cognitive abilities and functioning have been brought to normalcy because of using this drug.

The success of this drug in treating people with cognitive issues is well documented so there was need to test its success on the perfectly healthy individuals who have no sleep related disorders. Results have shown that Modafinil improves cognitive abilities such as conflict resolution, decision making and planning. Which bring us to the particular conclusion that Modafinil   is a great neuroenhancer for those with cognitive issues and those who are very normal.

Test that has been done over the year about the effectiveness of Modafinil to improve cognitive abilities haven’t gone far enough. Because there aren’t many out there that focus on normal adults.

New testing methods

It was until August 2015 that a team of researchers from Oxford and Harvard University reviewed all the studies undertaken so far on the effect of Modafinil on healthy adults.

They found that most studies tend to look at people with cognitive problems then make generalized blanket statements about the success (or lack of it).

The other problem has been the use of wrong and inappropriate cognitive tests.  Those that are meant for people with cognitive problems.    It doesn’t give a real account because individuals with no neurological disorders tend to do well in them without the help of neuroenhancers.  What researchers call the ‘ceiling effect’ which means that healthy adults would do well in such tests without the use of Modafinil?   So selecting inappropriate cognitive tests to lead to wrong conclusions because the drug viability of healthy adults isn’t tested.

Consequently, the researchers decided to use a broad range of tests to examine some of the benefits of Modafinil on normal and healthy adults.  Some of the things tested include learning, attention, memory and decision-making function. The impact of   Modafinil was much more evident because more appropriate tests had been used.

The test was so successful, and the results were so different that the researchers concluded that methods used to verify and assess the neuroenhancement are grossly inadequate.  There is a need for new, improved and better cognitive testing methods for perfectly healthy people to get good results.

Real enhancement

It is not new that you find people comparing neuroenhancers to steroids, but nothing could be more false. It is a wrong analogy because steroids create more muscles that you didn’t have while smart drugs such as Modafinil only use the brain that you have to get the best out of it; by putting it in the optimal chemical state.

It is not like you are turning Homer Simpson into Albert Einstein but turning Einstein into a better, high achieving version of himself. Imagine how many scientific discoveries would have been made.  Smart drugs enable you to do more because they make work become more enjoyable because you can focus more and thus achieve much with little effort.

There is no doubt that neuroenhancers such as Modafinil have great potential for the world now and in the days to come. Better learning and retention of information, better decision-making, and problem-solving.  Of course, improved cognition and enhanced brain power can result in the main breakthroughs in various human fields of interest.  Such as new discoveries in medicine and academia.

However, the potential moral dilemmas that this drug poses hangs around heavily like an enormous dark cloud. It isn’t easy to negotiate. There are those who consider using smart drugs as a form of cheating especially when used by students in an exam room to gain an edge over their colleagues. Or athletes using the drug to gain some extra push to the touchline.  But flatly rejecting the drug is like throwing out the baby with the bath water. There is so much to Modafinil than what it might mean to a student sitting for a paper.

Smart drugs can give you an extra five hours of work each day, and that can improve the work output.  If you don’t think that is much, consider that it would be an extra two hundred and fifty extra hours per year.  I am sure Einstein and Edison would rub their hands in glee at the prospect of getting half of that.

How Modafinil works

Modafinil operates in three main ways to ratchet up you cognitive abilities so that your brain keeps giving when you need it to, no matter the pressure that might be throwing your way.

  • It keeps the mind alert by maintaining a constant flow of blood to the brain
  • It increases energy levels because it ensures that the brain is refreshed all day long with energy to keep you working as long as you want.
  • It enhances the acetylcholine so that memory process and the learning function of the brain are up to date. The Modafinil stimulates the acetylcholine so that the brain is in an excellent chemical state that to learn as much as you may want.

 Future enhancement

The developments taking place can only be a good thing that has come at the right time. Neuroenhancers have a potential to improve our understanding of human ability. They can also help us to sincerely appreciate the world around, to build better relationships and become more innovative, productive and resilient.  However,   grave danger of abuse and harm that comes from these drugs remains. Possible side effects of Modafinil should not lead to outright rejection, but we need to look at ways of minimizing the potential effects.

One of the ways is to seek immediate medical attention in the event of side effects. To abide by the prescription as given by the doctor; taking an under or an over dose can have adverse consequences. Lastly, don’t self-prescribe. Ensure you have the green light of the doctor to make sure you are on the safe side.

There is also need for a societal debate on the efficiency and benefits of smart drugs because they are here to stay.  A Clear policy that deals with development and regulation of Modafinil should be far reaching but developed with the input of all key players.

References:

 

 

 


Modafinil ( Modalert ) vs. Armodafinil ( Waklert )

Is Armodafinil better than Modafinil? A question that many smart drug users would consider a head scratcher. But there isn’t much difference because both drugs have been approved by the FDA to treat daytime sleeping and promote wakefulness. In that sense, they are both considered eugeroic drugs.    The use of both has evolved from treating narcolepsy and other sleep-related disorders to performance enhancement.

The drugs have been used to boost brain power, enhance energy and productivity.  But many Nootropic users may not be sure what sort of drug is best suited to their needs. It is important to understand that Modafinil was first developed and tested in France by Lafon and approved for prescription in 1994.With a little modification and enhancement, Armodafinil came into existence in 2007.

It is widely considered an enantiomer of Modafinil because it has a modified chemical structure.  I understand why many smart drugs users need more than a simple yes or no when choosing between the two drugs.  Nootropic users want to know which drug has less harmful effects, the one that is cheaper and more efficient for performance enhancement.

These are some of the questions that many would be grappling with when selecting the ideal smart drug.  Despite the significant similarities that these drugs share they also have some differences that you need to know about; experiences and feelings that may not be captured in words.

Modafinil has grown in popularity over the years especially with professionals, athletes, and students in search of enhanced performance and productivity.  But little is known about the hotter cousin, ‘Armodafinil’ that does almost the same job.

Similarities of both drugs

Armodafinil and Modafinil are very similar drugs that are both used to promote wakefulness and treatment of sleep related disorders.   They are called eugeroic drugs because they promote wakefulness and they are less harmful compared to other psychostimulants that are highly addictive.  They are both approved by the FDA.

Modafinil (Modalert) and Armodafinil (Waklert) are increasingly used as performance enhancement supplements by athletes and students.  They have common side effects such as insomnia, nausea, headaches, and nervousness.  Modafinil and Armodafinil are both considered as ‘schedule IV’ in the United States which means that they have a low potential for abuse; one can have their prescriptions refilled up to 5 times in six months.

None of the drugs have any noticeable withdrawal symptoms and if there are any they don’t last long. Some of the common withdrawal symptoms include sleepiness and fatigue. Both drugs are manufactured in tablet form, are to be taken orally.  They both have a little potential for abuse when someone uses them as prescribed. However, abuse may happen if someone begins to self-prescribe or uses them to attain a ‘medical high.'  Armodafinil was developed to be a superior successor to Modafinil, but no hard evidence suggests that is certainly the case. Preference for both drugs tends to vary from personal experiences and individual variations. So what is the difference?

The most important difference that sets the two drugs apart is their chemical structure.  Modafinil is a racemic compound which means that it contains both ‘R’ and the ‘S’ enantiomer. Also, known as the left-handed and the right-handed enantiomers. It is like having a left and right hand that tends to have very different reactions. The enantiomers are very similar, but they have very different functions.

The ‘R’ enantiomers are considered the most useful and they help in stimulating the cognitive functions while the ‘S’ enantiomers are much less useful.  Armodafinil is an enhanced version of Modafinil because it contains only the useful and active enantiomer (R).

Thus, it is considered a more purified and pointed in its use because it only contains the most potent enantiomer.  For instance, the standard dosage of Modafinil required is about 200mg, but you only need 150mg of Armodafinil to achieve the same results of its predecessor.

Is Armodafinil better than Modafinil / Modalert for cognitive enhancement? You must have already come to that conclusion. Although it is not always that black and white. It isn’t as easy to choose between the two as  it sounds because the drugs tend to react differently.

These wonder drugs work differently from one person to another. Some reviews state that Modafinil is the best for mood enhancement, confidence and drive boosting while Armodafinil use may lead to nervousness and anxiety.  But Modafinil has also been accused of having same effects on the user.

So, this should not be taken as a definitive guide to help you when choosing between the two drugs. The route to take is to consult a licensed health physician before deciding whether to take Modafinil or Armodafinil.   You may want to have both Modafinil and Armodafinil so that you can have a first-hand experience the effects of the two drugs

Another difference is that users of Armodafinil will not experience a change in sleep patterns. You will still go to bed and wake up at regular times, but the users of Modafinil find it hard to sleep 5-10 hours after taking the drug.  While some consider this a positive thing, others think it is an adverse effect especially for those who want to stay awake.

The period of duration is another stark difference between these two drugs. The effects of Armodafinil lasts 2 hours more because of the R-enantiomer.  The S-enantiomer found in the Modafinil takes a much shorter timer. This means that the Armodafinil has the long-lasting lifespan, more efficient and potent compared to Modafinil.

Unlike Armodafinil, Modafinil is sold as a generic drug while the generic version of Armodafinil is still unavailable.      Packaging is another difference between the two drugs; Armodafinil is available in doses of 50 mg, 200 mg, and 250 mg while Modafinil is available as 100/200mg. There are some differences in the onset of action; while it takes 2 hours for Armodafinil, it might take 2-4 hours for Modafinil to take effect.

Side effects of both drugs

You must have heard the saying, ‘there is no biological free lunch.' That is certainly the case with all drugs. You should expect some effects, however, mild they might be if you use any drugs more so if they are as strong as most wakefulness agents tend to be.  Armodafinil and Modafinil share common side effects such as headaches, nausea, insomnia, and nervousness.

Some people think that ingesting a single ‘R’ enantiomer should have fewer side effects compared to swallowing both the ‘S’ and the ‘R’ enantiomers found in the Modafinil drug, but the strength of the effects vary from one person to another.   The side effects of the Armodafinil are expected to last longer because the effect of the drug also takes much more duration than Modafinil.

Furthermore, lower doses of the Armodafinil might have the more much more severe impact than a bigger dosage of Modafinil because the drug is much more potent and powerful.in some cases, there might be a severe reaction of the skin also known as the Stevens-Johnson syndrome.

 

However, it is important that there are not many significant differences as it relates to the usage of both drugs. The severity of side effects might be caused by differences in individual physiology and dosage of the drug that one has ingested.

Efficacy of both drugs

Some people speculate that Armodafinil drug is more potent compared to Modafinil because it has a single ‘R’ enantiomer compared to the Modafinil that has both ‘R’ and ‘S’ enantiomers.  Some say it is as twice as potent but how true that remains to be seen. In my view, it all comes to personal preferences and individual’s experience with the drug.

Both drugs have a therapeutic ceiling meaning beyond a given recommended dosage there can be no more effect.  The therapeutic limit for Modafinil is 200 mg per day while that of Armodafinil is thought to be about 150mg in a day.  The effects of Armodafinil sets in in about 2 hours after taking the drug while the onset of effects peaks at 2- 4 hours for Modafinil.

Modafinil helps to normalize sleep patterns for people who have sleep-related disorders such as narcolepsy and sleep apnea. Armodafinil has the same effects as Modafinil, but the only difference is that it doesn’t disrupt sleep patterns meaning that you can go to bed and wake up at the regular time.

The duration for the onset of effect is perhaps the clearest indication that Armodafinil might be more potent.  But asking about the potency of the drug may not give you a complete picture because there are those who prefer a drug for something else much more important; the experience of using a smart drug.  People have different experiences with drugs based on the effects that they have on them. With that in mind, there aren’t many significant discrepancies in the effects and effectiveness of both drugs.

Conclusion

Given that the two have similar effects, it is the matter of trying the two to find the one that works best for you.  If all of them work just fine for you, then it may have to come down to price.

References

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